*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : MJ6000000 CHEMICAL NAME : 3-Heptanone, 6-(dimethylamino)-4,4-diphenyl-, (S)- CAS REGISTRY NUMBER : 5653-80-5 BEILSTEIN REFERENCE NO. : 3213667 REFERENCE : 3-14-00-00279 (Beilstein Handbook Reference) LAST UPDATED : 199612 DATA ITEMS CITED : 6 MOLECULAR FORMULA : C21-H27-N-O MOLECULAR WEIGHT : 309.49 WISWESSER LINE NOTATION : 2VXR&R&1Y1&N1&1 COMPOUND DESCRIPTOR : Drug Mutagen Reproductive Effector SYNONYMS/TRADE NAMES : * Dextromethadone * d-6-(Dimethylamino)-4,4-diphenyl-3-heptanone * (S)-6-(Dimethylamino)-4,4-diphenyl-3-heptanone * (+)-Methadone * d-Methadone * L-(+)-Methadone * S-(+)-Methadone * 6S-Methadone *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 252 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 110,135,1954 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 74 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 9,280,1954 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 80 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 9,280,1954 ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE : 17800 ug/kg SEX/DURATION : male 1 day(s) pre-mating TOXIC EFFECTS : Reproductive - Paternal Effects - other effects on male REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 198,340,1976 ** MUTATION DATA ** TYPE OF TEST : DNA inhibition TEST SYSTEM : Rodent - rat Testis DOSE/DURATION : 50 umol/L REFERENCE : BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 27,123,1978 TYPE OF TEST : Mutation test systems - not otherwise specified TEST SYSTEM : Rodent - rat Testis DOSE/DURATION : 50 umol/L REFERENCE : BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 27,123,1978 *** END OF RECORD ***