*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : MJ9651150
CHEMICAL NAME           : 4-Heptenoic acid,
                          7-(5-((1,1'-biphenyl)-4-ylmethoxy)-2-(4-morpholinyl)-
                          3-oxocyclopentyl)-, (1-alpha(Z),2-beta,5-alpha)-(+-)-
CAS REGISTRY NUMBER     : 81443-73-4
BEILSTEIN REFERENCE NO. : 4279184
LAST UPDATED            : 199706
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C29-H35-N-O5
MOLECULAR WEIGHT        : 477.65
COMPOUND DESCRIPTOR     : Drug
                          Reproductive Effector
SYNONYMS/TRADE NAMES :
   * AH23848
 
                       *** HEALTH HAZARD DATA ***
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 750 mg/kg
SEX/DURATION            : female 12-16 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - body wall
REFERENCE :
   ParMM# Personal Communication from M.M. Parkinson, Glaxo Group Research
   Limited, Ware, Hertfordshire, SG12 0DJ, UK, Mar. 24, 1987
   Volume(issue)/page/year: 24MAR1987
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1500 mg/kg
SEX/DURATION            : female 12-16 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   TJADAB Teratology, The International Journal of Abnormal Development. (Alan
   R. Liss, Inc., 41 E. 11th St., New York, NY 10003)  V.1-    1968-
   Volume(issue)/page/year: 39,537,1989
 
                            *** END OF RECORD ***