*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : MJ9651180
CHEMICAL NAME           : 6-Heptenoic acid,
                          7-(4,5-bis(4-fluorophenyl)-2-(1-methylethyl)-1H-imida
                          zol-1-yl)-3,5- dihydroxy-, (S-(R*,S*-(E)))-
CAS REGISTRY NUMBER     : 129443-92-1
LAST UPDATED            : 199509
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C25-H26-N2-O4
MOLECULAR WEIGHT        : 418.53
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * GR95030X
 
                       *** HEALTH HAZARD DATA ***
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Primate - monkey
DOSE/DURATION           : 1085 mg/kg/49D-I
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - somnolence (general depressed activity)
   Related to Chronic Data - death
REFERENCE :
   HETOEA Human & Experimental Toxicology.  (Macmillan Press Ltd., Brunel Road,
   Houndmills, Basingstoke, Hampshire, RG21 2XS, UK) V.9- 1990-
   Volume(issue)/page/year: 13,357,1994
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Primate - monkey
DOSE/DURATION           : 4080 mg/kg/29W-I
TOXIC EFFECTS :
   Gastrointestinal - other changes
   Musculoskeletal - other changes
   Related to Chronic Data - death
REFERENCE :
   HETOEA Human & Experimental Toxicology.  (Macmillan Press Ltd., Brunel Road,
   Houndmills, Basingstoke, Hampshire, RG21 2XS, UK) V.9- 1990-
   Volume(issue)/page/year: 13,357,1994
 
                            *** END OF RECORD ***