*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : MK2830000
CHEMICAL NAME           : Heracleum rapula Franch, root extract
SUBSTANCE DEFINITION :
   Active ingredients include osthol and imperatorin
REFERENCE :
   CTYAD8 Zhongcaoyao.  Chinese Traditional and Herbal Medicine.  (China
   International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.11-
      1980-  Volume(issue)/page/year: 12,20,1981
LAST UPDATED            : 199506
DATA ITEMS CITED        : 1
COMPOUND DESCRIPTOR     : Natural Product
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1690 mg/kg
TOXIC EFFECTS :
   Behavioral - excitement
   Cardiac - other changes
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   CTYAD8 Zhongcaoyao.  Chinese Traditional and Herbal Medicine.  (China
   International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.11-
      1980-  Volume(issue)/page/year: 12,20,1981
 
                            *** END OF RECORD ***