*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : MO1294500
CHEMICAL NAME           : 1,6-Hexanediamine, N,N-diethyl-N(sup
                          1)-(6-methoxy-4-methyl-8-quinolinyl)-,
                          dihydrochloride
CAS REGISTRY NUMBER     : 5330-29-0
LAST UPDATED            : 199801
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C21-H33-N3-O.2Cl-H
MOLECULAR WEIGHT        : 416.49
COMPOUND DESCRIPTOR     : Drug
                          Reproductive Effector
SYNONYMS/TRADE NAMES :
   * 8-(6-Diethylaminohexylamino)-6-methoxy-4-methylquinoline dihydrochloride
   * N,N-Diethyl-N(sup 1)-(6-methoxy-4-methyl-8-quinolinyl)-1,6-hexanediamine  
   dihydrochloride
   * 8-Quinolinamine, 6-methoxy-N-(4-(2-piperidinyl)butyl)-, dihydrochloride
   * WR 29606
 
                       *** HEALTH HAZARD DATA ***
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1252 mg/kg/13W-I
TOXIC EFFECTS :
   Endocrine - changes in spleen weight
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
   Biochemical - Enzyme inhibition, induction, or change in blood or tissue
   levels - transaminases
REFERENCE :
   DDREDK Drug Development Research.  (Alan R. Liss, Inc., 41 E. 11th St., New
   York, NY 10003) V.1-    1981-  Volume(issue)/page/year: 40,75,1997
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 313 mg/kg/13W-I
TOXIC EFFECTS :
   Endocrine - changes in spleen weight
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
   Biochemical - Enzyme inhibition, induction, or change in blood or tissue
   levels - transaminases
REFERENCE :
   DDREDK Drug Development Research.  (Alan R. Liss, Inc., 41 E. 11th St., New
   York, NY 10003) V.1-    1981-  Volume(issue)/page/year: 40,75,1997
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 480 mg/kg
SEX/DURATION            : female 6-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Maternal Effects - other effects
REFERENCE :
   TOXID9 Toxicologist.  (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway,
   Akron, OH 44311) V.1-    1981-  Volume(issue)/page/year: 3,65,1983
 
                            *** END OF RECORD ***