*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : MO6350000
CHEMICAL NAME           : Hexanoic acid,
                          3-amino-6-((2-amino-4-methyl-1-oxopentyl)amino)-,
                          2-(carboxymethyl)-2- methylhydrazide, (S)-,
                          hemihydrate
LAST UPDATED            : 199510
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C15-H31-N5-O4.1/2H2-O
MOLECULAR WEIGHT        : 354.45
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Leucyl-3-epi-deoxynegamycin hemihydrate
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >400 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JANTAJ Journal of Antibiotics.  (Japan Antibiotics Research Assoc., 2-20-8
   Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan)  V.2-5, 1948-52;  V.21- 1968-
   Volume(issue)/page/year: 30,1137,1977
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 32500 mg/kg/13W-I
TOXIC EFFECTS :
   Cardiac - changes in heart weight
   Blood - changes in erythrocyte (RBC) count
   Blood - changes in leukocyte (WBC) count
REFERENCE :
   APTOA6 Acta Pharmacologica et Toxicologica.  (Copenhagen, Denmark)  V.1-59,
   1945-86.  For publisher information, see PHTOEH  Volume(issue)/page/year:
   22,340,1965
 
                            *** END OF RECORD ***