*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : MO8400000
CHEMICAL NAME           : Hexanoic acid, epsilon-lactone
CAS REGISTRY NUMBER     : 502-44-3
BEILSTEIN REFERENCE NO. : 0106919
REFERENCE               : 5-17-09-00034 (Beilstein Handbook Reference)
LAST UPDATED            : 199806
DATA ITEMS CITED        : 9
MOLECULAR FORMULA       : C6-H10-O2
MOLECULAR WEIGHT        : 114.16
WISWESSER LINE NOTATION : T7OVTJ
COMPOUND DESCRIPTOR     : Mutagen
SYNONYMS/TRADE NAMES :
   * Caprolactone
   * epsilon-Caprolactone
   * 6-Hexanolactone
   * 1,6-Hexanolide
   * 6-Hydroxyhexanoic acid lactone
   * epsilon-Kaprolakton
   * 2-Oxepanone
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 4290 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.
   (Chicago, IL)  V.2-10, 1950-54. For publisher information, see AEHLAU.
   Volume(issue)/page/year: 10,61,1954
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1300 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JJIND8 JNCI, Journal of the National Cancer Institute.  (Washington, DC)
   V.61-79, 1978-87. For publisher information, see JNCIEQ.
   Volume(issue)/page/year: 62,911,1979
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 5990 uL/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.
   (Chicago, IL)  V.2-10, 1950-54. For publisher information, see AEHLAU.
   Volume(issue)/page/year: 10,61,1954

                          *** STATUS IN U.S. ***
 
   EPA GENETOX PROGRAM 1988, Negative: SHE-clonal assay; Host-mediated assay
   
   EPA GENETOX PROGRAM 1988, Negative: L5178Y cells in vitro-TK test; E coli
   polA without S9
   
   EPA GENETOX PROGRAM 1988, Negative: E coli polA with S9; Histidine
   reversion-Ames test
   
   EPA GENETOX PROGRAM 1988, Negative: In vitro SCE-nonhuman; S
   cerevisiae-homozygosis
   
   EPA TSCA Section 8(b) CHEMICAL INVENTORY
   
   EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998

 
                            *** END OF RECORD ***