*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : MS3040000
CHEMICAL NAME           : L-Histidinamide,
                          5-oxo-L-propyl-N-(1-methyl-2-phenylethyl)-
CAS REGISTRY NUMBER     : 67543-14-0
BEILSTEIN REFERENCE NO. : 0944184
LAST UPDATED            : 199612
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C20-H25-N5-O3
MOLECULAR WEIGHT        : 383.50
WISWESSER LINE NOTATION : T5MVTJ EVMYVMY1&1R&1- DT5M CNJ
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * p-Glu-his-amph
   * 4-Imidazolepropionamide,  
   N-(alpha-methylphenethyl)-alpha-((2-oxo-5-pyrrolidinyl)formamido)-
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2400 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - excitement
   Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
   EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique.
   (Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France)
   V.9-    1974-  Volume(issue)/page/year: 14,425,1979
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 550 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - excitement
   Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
   EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique.
   (Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France)
   V.9-    1974-  Volume(issue)/page/year: 14,425,1979
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - species unspecified
DOSE/DURATION           : 2400 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BICMBE Biochimie.  (SPPIF, B.P.22, F-41353 Vineuil, France)  V.53-    1971-
   Volume(issue)/page/year: 63,495,1981
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Mammal - species unspecified
DOSE/DURATION           : 550 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BICMBE Biochimie.  (SPPIF, B.P.22, F-41353 Vineuil, France)  V.53-    1971-
   Volume(issue)/page/year: 63,495,1981
 
                            *** END OF RECORD ***