*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : MS3116100
CHEMICAL NAME           : Histidine, monohydrochloride, L-
CAS REGISTRY NUMBER     : 645-35-2
LAST UPDATED            : 199706
DATA ITEMS CITED        : 5
MOLECULAR FORMULA       : C6-H9-N3-O2.Cl-H
MOLECULAR WEIGHT        : 191.64
SYNONYMS/TRADE NAMES :
   * L-Histidine hydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 4407 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Lungs, Thorax, or Respiration - dyspnea
   Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
   ABBIA4 Archives of Biochemistry and Biophysics.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802)  V.31-    1951-  Volume(issue)/page/year:
   64,319,1956
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 697 gm/kg/2Y-C
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - changes in lung weight
   Blood - pigmented or nucleated red blood cells
   Blood - changes in erythrocyte (RBC) count
REFERENCE :
   FCTOD7 Food and Chemical Toxicology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.20-    1982- Volume(issue)/page/year:
   34,687,1996

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOHS - National Occupational Hazard Survey (1974)
     NOHS Hazard Code - 82261
       No. of Facilities: 59 (estimated)
       No. of Industries: 3
       No. of Occupations: 3
       No. of Employees: 744 (estimated)
   
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - 82261
       No. of Facilities: 196 (estimated)
       No. of Industries: 1
       No. of Occupations: 5
       No. of Employees: 2601 (estimated)
       No. of Female Employees: 1791 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA TSCA Section 8(b) CHEMICAL INVENTORY

 
                            *** END OF RECORD ***