*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : MU2452120
CHEMICAL NAME           : Hydantoin, 5-ethyl-5-phenyl-, (+)-
CAS REGISTRY NUMBER     : 65567-34-2
BEILSTEIN REFERENCE NO. : 0085311
REFERENCE               : 5-24-08-00092 (Beilstein Handbook Reference)
LAST UPDATED            : 199612
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C11-H12-N2-O2
MOLECULAR WEIGHT        : 204.25
COMPOUND DESCRIPTOR     : Drug
                          Human
SYNONYMS/TRADE NAMES :
   * (+)-5-Ethyl-5-phenylhydantoin
   * (S)-5-Ethyl-5-phenyl-2,4-imidazolidinedione
   * 2,4-Imidazolidinedione, 5-ethyl-5-phenyl-, (S)-
   * (+)-Nirvanol
   * (S)-Nirvanol
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - child
DOSE/DURATION           : 140 mg/kg
TOXIC EFFECTS :
   Skin and Appendages - dermatitis, allergic (after systemic exposure)
   Nutritional and Gross Metabolic - body temperature increase
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 47,209,1933
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BBIADT Biomedica Biochimica Acta.  (Akademie-Verlag GmbH, Postfach 1233,
   Berlin DDR-1086, Ger. Dem. Rep.)  V.42-     1983-  Volume(issue)/page/year:
   46,623,1987
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 175 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 47,209,1933
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 47,209,1933
 
                            *** END OF RECORD ***