*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : MU2452130
CHEMICAL NAME : Hydantoin, 5-ethyl-5-phenyl-, (+-)-
CAS REGISTRY NUMBER : 2216-93-5
LAST UPDATED : 198910
DATA ITEMS CITED : 3
MOLECULAR FORMULA : C11-H12-N2-O2
MOLECULAR WEIGHT : 204.25
COMPOUND DESCRIPTOR : Drug
Human
SYNONYMS/TRADE NAMES :
* (+-)-5-Ethyl-5-phenylhydantoin
* 2,4-Imidazolidinedione, 5-ethyl-5-phenyl-, (+-)-
* (+-)-Nirvanol
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - child
DOSE/DURATION : 210 mg/kg
TOXIC EFFECTS :
Skin and Appendages - dermatitis, allergic (after systemic exposure)
Nutritional and Gross Metabolic - body temperature increase
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 47,209,1933
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 125 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 47,209,1933
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 47,209,1933
*** END OF RECORD ***