*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : MU3874000
CHEMICAL NAME           : Hydantoin, 1-((5-(p-nitrophenyl)furfurylidene)amino)-
CAS REGISTRY NUMBER     : 7261-97-4
BEILSTEIN REFERENCE NO. : 0705189
REFERENCE               : 5-24-05-00226 (Beilstein Handbook Reference)
LAST UPDATED            : 199612
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C14-H10-N4-O5
MOLECULAR WEIGHT        : 314.28
COMPOUND DESCRIPTOR     : Tumorigen
                          Drug
                          Human
SYNONYMS/TRADE NAMES :
   * Dantrolene
   * 2,4-Imidazolidinedione,  
   1-(((5-(4-nitrophenyl)-2-furanyl)methylene)amino)-
   * 1-(((5-(4-Nitrophenyl)-2-furanyl)methylene)amino)-2,4-imidazolidinedione
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >7 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 21,127,1978
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 9386 mg/kg/3Y-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Blood - lymphoma, including Hodgkin's disease
REFERENCE :
   PGMJAO Postgraduate Medical Journal.  (Blackwell Scientific Pub. Ltd., POB
   88, Oxford, UK) V.1-    1925-  Volume(issue)/page/year: 56,261,1980
 
                            *** END OF RECORD ***