*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : MV2275000
CHEMICAL NAME           : Hydrazine, 1,2-diethyl-
CAS REGISTRY NUMBER     : 1615-80-1
BEILSTEIN REFERENCE NO. : 1731367
REFERENCE               : 4-04-00-03336 (Beilstein Handbook Reference)
LAST UPDATED            : 199701
DATA ITEMS CITED        : 15
MOLECULAR FORMULA       : C4-H12-N2
MOLECULAR WEIGHT        : 88.18
WISWESSER LINE NOTATION : 2MM2
COMPOUND DESCRIPTOR     : Tumorigen
                          Mutagen
                          Reproductive Effector
SYNONYMS/TRADE NAMES :
   * 1,2-Diaethylhydrazin
   * N-N'-Diethylhydrazine
   * sym-Diethylhydrazine
   * 1,2-Diethylhydrazine
   * Hydrazoethane
   * Hydroazoethane
   * RCRA waste number U086
   * SDEH
 
                       *** HEALTH HAZARD DATA ***
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 700 mg/kg/28W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Brain and Coverings - tumors
   Blood - leukemia
REFERENCE :
   NATWAY Naturwissenschaften.  (Springer-Verlag, Heidelberger Platz 3, D-1000
   Berlin 33, Fed. Rep. Ger.)  V.1-    1913-  Volume(issue)/page/year:
   53,557,1966
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 50 mg/kg
                          female 15 day(s) after conception
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Reproductive - Tumorigenic effects - transplacental tumorigenesis
   Brain and Coverings - tumors
REFERENCE :
   IARCCD IARC Scientific Publications.  (Geneva, Switzerland)  No.1-26,
   1971-78.  For publisher information, see IAPUDO.  Volume(issue)/page/year:
   4,45,1973
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 150 mg/kg
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Endocrine - thyroid tumors
   Blood - leukemia
REFERENCE :
   CALEDQ Cancer Letters (Shannon, Ireland).  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-    1975- Volume(issue)/page/year:
   67,21,1992
 
TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 50 mg/kg
                          female 15 day(s) after conception
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Reproductive - Tumorigenic effects - transplacental tumorigenesis
   Brain and Coverings - tumors
REFERENCE :
   FCTXAV Food and Cosmetics Toxicology.  (London, UK)  V.1-19, 1963-81.  For
   publisher information, see FCTOD7.  Volume(issue)/page/year: 6,584,1968
 
TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1850 mg/kg/37W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Brain and Coverings - tumors
REFERENCE :
   XENOBH Xenobiotica.  (Taylor & Francis Ltd., 4 John St., London WC1N 2ET,
   UK)  V.1-    1971-  Volume(issue)/page/year: 3,271,1973
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 10 mg/kg
SEX/DURATION            : female 15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - eye/ear
REFERENCE :
   XENOBH Xenobiotica.  (Taylor & Francis Ltd., 4 John St., London WC1N 2ET,
   UK)  V.1-    1971-  Volume(issue)/page/year: 3,271,1973
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 500 mg/kg
SEX/DURATION            : female 15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
   IARCCD IARC Scientific Publications.  (Geneva, Switzerland)  No.1-26,
   1971-78.  For publisher information, see IAPUDO.  Volume(issue)/page/year:
   4,45,1973
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 83200 nmol/plate
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 278,215,1992

                              *** REVIEWS ***
 
   IARC Cancer Review:Animal Sufficient Evidence
   IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
   to Man.  (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
   V.1-    1972-  Volume(issue)/page/year: 4,153,1974

   IARC Cancer Review:Human No Adequate Data
   IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
   to Man.  (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
   V.1-    1972-  Volume(issue)/page/year: 4,153,1974

   IARC Cancer Review:Group 2B
   IMSUDL IARC Monographs, Supplement.  (WHO Publications Centre USA, 49
   Sheridan Ave., Albany, NY 12210)  No.1-    1979-  Volume(issue)/page/year:
   7,56,1987

   TOXICOLOGY REVIEW
   32XPAD "Teratology," Berry, C.L., and D.E. Poswillo, eds., New York,
   Springer, 1975  Volume(issue)/page/year: -,49,1975

                    *** OCCUPATIONAL EXPOSURE LIMITS ***
 
   OEL-FRANCE;Carcinogen JAN 1993

                          *** STATUS IN U.S. ***
 
   EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat
   
   On EPA IRIS database

 
                            *** END OF RECORD ***