*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : MR8159000
CHEMICAL NAME           : Hippuric acid, compd. with hexamethylenetetramine
                          (1:1)
CAS REGISTRY NUMBER     : 5714-73-8
LAST UPDATED            : 199504
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C9-H9-N-O3.C6-H12-N4
MOLECULAR WEIGHT        : 319.41
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Glycine, N-benzoyl-, compd. with 1,3,5,7-tetraazatricyclo(3.3.1.1(sup  
   3,7))decane (1:1)
   * Haiprex
   * Hexamethylenetetramine hippurate
   * Hippramine
   * Hiprex
   * Methenamine hippurate
   * R-657
   * Viapta
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1500 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   NKRZAZ Chemotherapy (Tokyo).  (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki,
   Shinagawa-Ku, Tokyo 141, Japan)  V.1-    1953- Volume(issue)/page/year:
   16,328,1968
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2870 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   NKRZAZ Chemotherapy (Tokyo).  (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki,
   Shinagawa-Ku, Tokyo 141, Japan)  V.1-    1953- Volume(issue)/page/year:
   16,328,1968

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOHS - National Occupational Hazard Survey (1974)
     NOHS Hazard Code - 82903
       No. of Facilities: 14 (estimated)
       No. of Industries: 1
       No. of Occupations: 4
       No. of Employees: 504 (estimated)
   
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - 82903
       No. of Facilities: 16 (estimated)
       No. of Industries: 1
       No. of Occupations: 1
       No. of Employees: 94 (estimated)
       No. of Female Employees: 62 (estimated)

 
                            *** END OF RECORD ***