*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : MW6300000
CHEMICAL NAME           : Hydrocupreine, O-ethyl-, hydrochloride
CAS REGISTRY NUMBER     : 3413-58-9
LAST UPDATED            : 199504
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C21-H28-N2-O2.Cl-H
MOLECULAR WEIGHT        : 376.97
WISWESSER LINE NOTATION : T66 BNJ HO2 EYQ- DT66 A B CNTJ G2 &GH
COMPOUND DESCRIPTOR     : Drug
                          Human
SYNONYMS/TRADE NAMES :
   * Ethylhydrocupreine hydrochloride
   * Hydrocupreine, ethyl ester, hydrochloride
   * Neumolisina
   * Numoquin hydrochloride
   * Optochin hydrochloride
   * Optoquinhydrochloride
   * Rhombic
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 31 mg/kg/3D
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - visual field changes
   Vascular - regional or general arteriolar constriction
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 8,53,1916
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 500 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - somnolence (general depressed activity)
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 8,53,1916
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Amphibian - frog
DOSE/DURATION           : 300 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - somnolence (general depressed activity)
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 8,53,1916

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - X5575
       No. of Facilities: 90 (estimated)
       No. of Industries: 1
       No. of Occupations: 2
       No. of Employees: 557 (estimated)
       No. of Female Employees: 502 (estimated)

 
                            *** END OF RECORD ***