*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : MX0899000
CHEMICAL NAME : Hydrogen peroxide, 30%
CAS REGISTRY NUMBER : 7722-84-1
LAST UPDATED : 199712
DATA ITEMS CITED : 40
MOLECULAR FORMULA : H2-O2
MOLECULAR WEIGHT : 34.02
WISWESSER LINE NOTATION : QQ
COMPOUND DESCRIPTOR : Tumorigen
Mutagen
Human
SYNONYMS/TRADE NAMES :
* Albone 35
* Albone 50
* Albone 70
* Albone 35CG
* Albone 50CG
* Albone 70CG
* Hydrogen peroxide, solution, 30%
* Interox
* Kastone
* Perone 30
* Perone 35
* Perone 50
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - woman
DOSE/DURATION : 2626 ug/kg
TOXIC EFFECTS :
Behavioral - coma
Lungs, Thorax, or Respiration - cyanosis
Gastrointestinal - nausea or vomiting
REFERENCE :
SMEZA5 Sudebno-Meditsinskaya Ekspertiza. Forensic Medical Examination. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1958-
Volume(issue)/page/year: 17(1),53,1974
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - man
DOSE/DURATION : 1429 mg/kg
TOXIC EFFECTS :
Behavioral - coma
Gastrointestinal - changes in structure or function of esophagus
Gastrointestinal - nausea or vomiting
REFERENCE :
SMEZA5 Sudebno-Meditsinskaya Ekspertiza. Forensic Medical Examination. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1958-
Volume(issue)/page/year: 17(1),53,1974
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - woman
DOSE/DURATION : 1200 mg/kg
TOXIC EFFECTS :
Gastrointestinal - gastritis
Gastrointestinal - nausea or vomiting
REFERENCE :
AEMED3 Annals of Emergency Medicine. (American College of Emergency
Physicians, 1125 Executive Circle, Irving, TX 75038)
Volume(issue)/page/year: 21,1391,1992
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : >50 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HYHPDO Hunan Yixueyuan Xuebao. Journal of Hunan Medical College. (China
International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China)
Beginning history not known. Volume(issue)/page/year: 5,39,1980
** TUMORIGENIC DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 622 gm/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Gastrointestinal - tumors
REFERENCE :
HIUN** Department of Cancer Research, Research Institute for Nuclear
Medicine and Biology, Hiroshima University. (Kasumi 1-2-3, Hiroshima 734,
Japan)
TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 155 gm/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Gastrointestinal - tumors
REFERENCE :
HIUN** Department of Cancer Research, Research Institute for Nuclear
Medicine and Biology, Hiroshima University. (Kasumi 1-2-3, Hiroshima 734,
Japan)
** MUTATION DATA **
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 4400 umol/plate
REFERENCE :
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc.,
41 E. 11th St., New York, NY 10003) V.1- 1980- Volume(issue)/page/year:
9,211,1989
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Mold - Neurospora crassa
DOSE/DURATION : 500 nnmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 374,169,1997
TYPE OF TEST : DNA damage
TEST SYSTEM : Human Lymphocyte
DOSE/DURATION : 9 umol/L
REFERENCE :
ECREAL Experimental Cell Research. (Academic Press, Inc., 1 E. First St.,
Duluth, MN 55802) V.10- 1950- Volume(issue)/page/year: 175,184,1988
TYPE OF TEST : Mutation test systems - not otherwise specified
TEST SYSTEM : Human Embryo
DOSE/DURATION : 50 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 172,245,1986
TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Human Embryo
DOSE/DURATION : 20 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 172,245,1986
TYPE OF TEST : DNA damage
TEST SYSTEM : Rodent - rat Lymphocyte
DOSE/DURATION : 50 umol/L
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
Volume(issue)/page/year: 23,407,1988
TYPE OF TEST : DNA inhibition
TEST SYSTEM : Rodent - hamster Ovary
DOSE/DURATION : 250 umol/L
REFERENCE :
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland
Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year:
76,129,1990
TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Rodent - hamster Ovary
DOSE/DURATION : 60 umol/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E.
11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year:
26,248,1995
TYPE OF TEST : Sister chromatid exchange
TEST SYSTEM : Rodent - hamster Ovary
DOSE/DURATION : 40 umol/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E.
11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year:
26,248,1995
TYPE OF TEST : Mutation in mammalian somatic cells
TEST SYSTEM : Rodent - hamster Lung
DOSE/DURATION : 1 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 192,65,1987
*** REVIEWS ***
IARC Cancer Review:Animal Limited Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 36,285,1985
IARC Cancer Review:Group 3
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year:
7,56,1987
*** U.S. STANDARDS AND REGULATIONS ***
EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year:
54,7740,1989
MSHA STANDARD-air:TWA 1 ppm (1.4 mg/m3)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,131,1971
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 1 ppm (1.5 mg/m3) JAN 1993
OEL-BELGIUM:TWA 1 ppm (1.4 mg/m3) JAN 1993
OEL-DENMARK:TWA 1 ppm (1.4 mg/m3) JAN 1993
OEL-FINLAND:TWA 1 ppm (1.4 mg/m3);STEL 3 ppm (4.2 mg/m3) JAN 1993
OEL-FRANCE:TWA 1 ppm (1.5 mg/m3) JAN 1993
OEL-GERMANY:TWA 1 ppm (1.4 mg/m3) JAN 1993
OEL-THE NETHERLANDS:TWA 1 ppm (1.4 mg/m3) JAN 1993
OEL-THE PHILIPPINES:TWA 1 ppm (1.4 mg/m3) JAN 1993
OEL-SWITZERLAND:TWA 1 ppm (1.4 mg/m3);STEL 2 ppm (2.8 mg/m3) JAN 1993
OEL-TURKEY:TWA 1 ppm (1.4 mg/m3) JAN 1993
OEL-UNITED KINGDOM:TWA 1 ppm (1.5 mg/m3);STEL 2 ppm (3 mg/m3) JAN 1993
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 38605
No. of Facilities: 19597 (estimated)
No. of Industries: 168
No. of Occupations: 83
No. of Employees: 422227 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 38605
No. of Facilities: 22930 (estimated)
No. of Industries: 171
No. of Occupations: 142
No. of Employees: 1006752 (estimated)
No. of Female Employees: 727702 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: N crassa-reversion; E coli polA without
S9
EPA GENETOX PROGRAM 1988, Positive: In vitro UDS-human fibroblast; S
pombe-reversion
EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-8799
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
*** END OF RECORD ***