*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : MX3016000
CHEMICAL NAME           : Hydroquinidine
CAS REGISTRY NUMBER     : 1435-55-8
LAST UPDATED            : 199607
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C20-H26-N2-O2
MOLECULAR WEIGHT        : 326.48
COMPOUND DESCRIPTOR     : Drug
                          Human
SYNONYMS/TRADE NAMES :
   * Cinchonan-9-ol, 10,11-dihydro-6'-methoxy-, (9S)-
   * (9S)-10,11-Dihydro-6'-methoxycinchonan-9-ol
   * Dihydroquinidine
   * 10,11-Dihydroquinidine
   * Hydroconquinine
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 12 mg/kg
TOXIC EFFECTS :
   Behavioral - hallucinations, distorted perceptions
   Behavioral - headache
   Cardiac - EKG changes not diagnostic of specified effects
REFERENCE :
   CTOXAO Clinical Toxicology.  (New York, NY)  V.1-18, 1968-81.  For publisher
   information, see JTCTDW.  Volume(issue)/page/year: 18,659,1981
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 56500 ug/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 84,184,1945
 
                            *** END OF RECORD ***