*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : NC3411500
CHEMICAL NAME : Hydroxylamine, N,O-diacetyl-N-(4-biphenylyl)-
CAS REGISTRY NUMBER : 26541-56-0
BEILSTEIN REFERENCE NO. : 2812954
REFERENCE : 2-15-00-00020 (Beilstein Handbook Reference)
LAST UPDATED : 199612
DATA ITEMS CITED : 9
MOLECULAR FORMULA : C16-H15-N-O3
MOLECULAR WEIGHT : 269.32
WISWESSER LINE NOTATION : 1VONV1&R DR
COMPOUND DESCRIPTOR : Tumorigen
Mutagen
SYNONYMS/TRADE NAMES :
* Acetamide, N-(acetyloxy)-N-(1,1'-biphenyl)-4-yl-
* Acetanilide, 4-phenyl-, N-acetate (ester)
* Acetic acid, (N-acetyl-N-(4-biphenyl)amino) ester
* Acetic acid, ester with N-4-biphenylylacetohydroxamic acid
* Acetohydroxamic acid, N-(4-biphenylyl)-, acetate
* N-Acetoxy-4-acetamidobiphenyl
* N-Acetoxy-4-acetylaminobiphenyl
* N-Acetoxy-4-biphenylacetamide
* N-(Acetyloxy)-N-(1,1'-biphenyl)-4-ylacetamide
* N-(4-Biphenylyl)acetohydroxamic acetate
* N-(4-Biphenylyl)acetohydroxamic acid acetate
* N,O-Diacetyl-N-(4-biphenylyl)hydroxylamine
*** HEALTH HAZARD DATA ***
** TUMORIGENIC DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 4309 ug/kg
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Skin and Appendages - tumors
Tumorigenic - tumors at site of application
REFERENCE :
JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60,
1940-78. For publisher information, see JJIND8. Volume(issue)/page/year:
54,491,1975
** MUTATION DATA **
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 10 ug/plate
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E.
11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year:
17,84,1991
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 5 ug/plate
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E.
11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year:
20,61,1992
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Bacillus subtilis
DOSE/DURATION : 7 mol
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
30,1473,1970
TYPE OF TEST : Mutation test systems - not otherwise specified
TEST SYSTEM : Bacteria - Bacillus subtilis
DOSE/DURATION : 10 gm/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
30,1473,1970
TYPE OF TEST : Unscheduled DNA synthesis
TEST SYSTEM : Human Fibroblast
DOSE/DURATION : 10 umol/L/5H
REFERENCE :
IJCNAW International Journal of Cancer. (International Union Against
Cancer, 3 rue du Conseil- General, 1205 Geneva, Switzerland) V.1- 1966-
Volume(issue)/page/year: 16,284,1975
TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Rodent - hamster Ovary
DOSE/DURATION : 2900 nmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 88,397,1981
TYPE OF TEST : Sister chromatid exchange
TEST SYSTEM : Rodent - hamster Ovary
DOSE/DURATION : 2900 nmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 88,397,1981
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: In vitro UDS-human fibroblast
*** END OF RECORD ***