*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : NC3440000
CHEMICAL NAME           : Hydroxylamine, N,O-diacetyl-N-(p-styrylphenyl)-
CAS REGISTRY NUMBER     : 26594-44-5
BEILSTEIN REFERENCE NO. : 2751068
LAST UPDATED            : 199612
DATA ITEMS CITED        : 6
MOLECULAR FORMULA       : C18-H17-N-O3
MOLECULAR WEIGHT        : 295.36
WISWESSER LINE NOTATION : 1VONV1&1U1R DR
COMPOUND DESCRIPTOR     : Tumorigen
                          Mutagen
SYNONYMS/TRADE NAMES :
   * Acetamide, N-(acetyloxy)-N-(4-(2-phenylethenyl)phenyl)-
   * Acetic acid, (N-acetyl-N-(p-styrylphenyl)amino) ester
   * Acetic acid, ester with N-(p-styrylphenyl)acetohydroxamic acid
   * Acetohydroxamic acid, N-(p-styrylphenyl)-, acetate
   * N-Acetoxy-4-acetamidostilbene
   * N-Acetoxy-4-acetylaminostilbene
   * N-Acetoxy-N-(4-stilbenyl)-acetamide
   * N-(Acetyloxy)-N-(4-(2-phenylethenyl)phenyl)acetamide
   * N,O-Diacetyl-N-(p-styrylphenyl)hydroxylamine
   * N-(p-Styrylphenyl)acetohydroxamic acetate
   * N-(p-Styrylphenyl)acetohydroxamic acid acetate
 
                       *** HEALTH HAZARD DATA ***
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2360 ug/kg
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Skin and Appendages - tumors
   Tumorigenic - tumors at site of application
REFERENCE :
   JNCIAM Journal of the National Cancer Institute.  (Washington, DC)  V.1-60,
   1940-78.  For publisher information, see JJIND8.  Volume(issue)/page/year:
   54,491,1975
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 5 ug/plate
REFERENCE :
   CBINA8 Chemico-Biological Interactions.  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-    1969-  Volume(issue)/page/year:
   26,11,1979
 
TYPE OF TEST            : Unscheduled DNA synthesis
TEST SYSTEM             : Human Fibroblast
DOSE/DURATION           : 10 umol/L/5H
REFERENCE :
   IJCNAW International Journal of Cancer.  (International Union Against
   Cancer, 3 rue du Conseil- General, 1205 Geneva, Switzerland)  V.1-    1966-
   Volume(issue)/page/year: 16,284,1975
 
TYPE OF TEST            : Unscheduled DNA synthesis
TEST SYSTEM             : Human HeLa cell
DOSE/DURATION           : 100 nmol/L
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   38,2621,1978

                          *** STATUS IN U.S. ***
 
   EPA GENETOX PROGRAM 1988, Positive: In vitro UDS-human fibroblast
   
   EPA GENETOX PROGRAM 1988, Positive/limited: Carcinogenicity-mouse/rat

 
                            *** END OF RECORD ***