*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : NC3560500 CHEMICAL NAME : Hydroxylamine, N-(2',3-dimethylbiphenyl-4-yl)- CAS REGISTRY NUMBER : 70786-72-0 BEILSTEIN REFERENCE NO. : 2834261 LAST UPDATED : 199612 DATA ITEMS CITED : 6 MOLECULAR FORMULA : C14-H15-N-O MOLECULAR WEIGHT : 213.30 WISWESSER LINE NOTATION : QMR B1 DR B1 COMPOUND DESCRIPTOR : Tumorigen Mutagen SYNONYMS/TRADE NAMES : * (1,1'-Biphenyl)-4-amine, 2',3-dimethyl-N-hydroxy- * 4-N-(3,2'-Dimethylbiphenyl)hydroxamine * 2',3-Dimethyl-N-hydroxy-(1,1'-biphenyl)-4-amine * N-Hydroxy-3,2'-dimethyl-4-aminobiphenyl *** HEALTH HAZARD DATA *** ** TUMORIGENIC DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 200 mg/kg/20W-I TOXIC EFFECTS : Tumorigenic - Carcinogenic by RTECS criteria Reproductive - Tumorigenic effects - prostate tumors REFERENCE : JJCREP Japanese Journal of Cancer Research. (Elsevier Science Pub. BV, POB 211, 1000 AE Amsterdam, Netherlands) V.76- 1985- Volume(issue)/page/year: 83,695,1992 TYPE OF TEST : TD - Toxic dose (other than lowest) ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 50 mg/kg/60W-I TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Reproductive - Tumorigenic effects - prostate tumors REFERENCE : JJCREP Japanese Journal of Cancer Research. (Elsevier Science Pub. BV, POB 211, 1000 AE Amsterdam, Netherlands) V.76- 1985- Volume(issue)/page/year: 81,320,1990 ** MUTATION DATA ** TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Bacteria - Salmonella typhimurium DOSE/DURATION : 120 nmol REFERENCE : JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 22,981,1979 TYPE OF TEST : Unscheduled DNA synthesis TEST SYSTEM : Rodent - rat Mammary gland DOSE/DURATION : 10 umol/L REFERENCE : CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 48,4227,1988 TYPE OF TEST : Unscheduled DNA synthesis TEST SYSTEM : Rodent - rat Cells - not otherwise specified DOSE/DURATION : 1 umol/L REFERENCE : CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 48,4227,1988 TYPE OF TEST : Unscheduled DNA synthesis TEST SYSTEM : Mammal - dog Cells - not otherwise specified DOSE/DURATION : 10 umol/L REFERENCE : CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 48,4227,1988 *** END OF RECORD ***