*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : NF9125000
CHEMICAL NAME           : Hydroxypropyl methylcellulose
CAS REGISTRY NUMBER     : 9004-65-3
OTHER CAS REGISTRY NOS. : 8063-82-9
                          62683-26-5
LAST UPDATED            : 199710
DATA ITEMS CITED        : 7
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Goniosol
   * Hpmcd
   * Isopto alkaline
   * Isopto plain
   * Isopto tears
   * Methocel E,F,K
   * Methocel HG
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 5200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 99,112,1950
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 5 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 99,112,1950
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2250 gm/kg/30D-C
TOXIC EFFECTS :
   Gastrointestinal - hypermotility, diarrhea
   Related to Chronic Data - death
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 99,112,1950

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOHS - National Occupational Hazard Survey (1974)
     NOHS Hazard Code - 83974
       No. of Facilities: 3348 (estimated)
       No. of Industries: 22
       No. of Occupations: 30
       No. of Employees: 33421 (estimated)
   
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - X5876
       No. of Facilities: 11342 (estimated)
       No. of Industries: 65
       No. of Occupations: 75
       No. of Employees: 188173 (estimated)
       No. of Female Employees: 87912 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA TSCA Section 8(b) CHEMICAL INVENTORY
   
   EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998

 
                            *** END OF RECORD ***