*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : NH0875000
CHEMICAL NAME           : Hyoscyamine, (-)-
CAS REGISTRY NUMBER     : 101-31-5
LAST UPDATED            : 199701
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C17-H23-N-O3
MOLECULAR WEIGHT        : 289.41
WISWESSER LINE NOTATION : T56 A ANTJ A1 GOVYR&1Q  -L
COMPOUND DESCRIPTOR     : Human
                          Natural Product
SYNONYMS/TRADE NAMES :
   * (-)-Atropine
   * Daturine
   * Duboisine
   * Hyoscyamine
   * (-)-Hyoscyamine
   * 1-Hyoscyamine
   * Levsin
   * Tropic acid, (-)-, ester with tropine
   * Tropine, (-)-tropate (ester)
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 1471 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85DCAI "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M.,
   Springfield, IL, C.C. Thomas, 1970  Volume(issue)/page/year: 2,73,1970
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 95 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - effect, not otherwise specified
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   BJPCAL British Journal of Pharmacology and Chemotherapy.  (London, UK)
   V.1-33, 1946-68.  For publisher information, see BJPCBM.
   Volume(issue)/page/year: 24,138,1965

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOHS - National Occupational Hazard Survey (1974)
     NOHS Hazard Code - A1029
       No. of Facilities: 68 (estimated)
       No. of Industries: 1
       No. of Occupations: 6
       No. of Employees: 2770 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA TSCA Section 8(b) CHEMICAL INVENTORY

 
                            *** END OF RECORD ***