*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : NI2922200
CHEMICAL NAME           : 4H-Imidazo(1,5-a)(1,4)benzodiazepine,
                          8-chloro-6-(2-fluorophenyl)-1-methyl-,
                          (Z)-2-butenedioate (1:1)
CAS REGISTRY NUMBER     : 59467-94-6
OTHER CAS REGISTRY NOS. : 65607-69-4
LAST UPDATED            : 199707
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C18-H13-Cl-F-N3.C4-H4-O4
MOLECULAR WEIGHT        : 441.87
WISWESSER LINE NOTATION : T B576 BN DN HN GHJ C1 IR BF& LG &QV1U1VQ
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * 8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo(1,5-a)(1,4)benzodiazepine 
    maleate
   * Dormicum
   * Dormicum maleate
   * Midazolam maleate
   * Ro 21-3981/001
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 760 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 31,2180,1981
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 86 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 31,2180,1981
 
                            *** END OF RECORD ***