*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : NI2922250
CHEMICAL NAME           : 4H-Imidazo(1,5-a)(1,4)benzodiazepine,
                          8-chloro-6-(2-fluorophenyl)-1-methyl-, hydrochloride
CAS REGISTRY NUMBER     : 59467-96-8
LAST UPDATED            : 199706
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C18-H13-Cl-F-N3.Cl-H
MOLECULAR WEIGHT        : 362.25
COMPOUND DESCRIPTOR     : Drug
                          Human
SYNONYMS/TRADE NAMES :
   * 8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo(1,5-a)(1,4)benzodiazepine 
    hydrochloride
   * Hypnovel
   * Midazolam hydrochloride
   * Rocam
   * Versed
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Human - child
DOSE/DURATION           : 200 ug/kg
TOXIC EFFECTS :
   Skin and Appendages - dermatitis, allergic (after systemic exposure)
   Skin and Appendages - primary irritation (after topical exposure)
   Immunological Including Allergic - other immediate (humoral): urticaria,
   allergic rhinitis, serum sickness
REFERENCE :
   BMJOAE British Medical Journal.  (British Medical Assoc., BMA House,
   Tavistock Sq., London WC1H 9JR, UK)  V.1-    1857- Volume(issue)/page/year:
   293,822,1986
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Human - child
DOSE/DURATION           : 22 mg/kg/4D-I
TOXIC EFFECTS :
   Liver - other changes
   Blood - change in clotting factors
REFERENCE :
   BMJOAE British Medical Journal.  (British Medical Assoc., BMA House,
   Tavistock Sq., London WC1H 9JR, UK)  V.1-    1857- Volume(issue)/page/year:
   289,799,1984
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 71 ug/kg
TOXIC EFFECTS :
   Skin and Appendages - dermatitis, allergic (after systemic exposure)
   Skin and Appendages - primary irritation (after topical exposure)
   Immunological Including Allergic - other immediate (humoral): urticaria,
   allergic rhinitis, serum sickness
REFERENCE :
   BMJOAE British Medical Journal.  (British Medical Assoc., BMA House,
   Tavistock Sq., London WC1H 9JR, UK)  V.1-    1857- Volume(issue)/page/year:
   293,822,1986
 
                            *** END OF RECORD ***