*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : NI2935500
CHEMICAL NAME : 3H-Imidazo(2,1-c)-1,2,4-dithiazole-3-thione,
5,6-dihydro-
CAS REGISTRY NUMBER : 33813-20-6
BEILSTEIN REFERENCE NO. : 0006205
REFERENCE : 4-27-00-08745 (Beilstein Handbook Reference)
LAST UPDATED : 199806
DATA ITEMS CITED : 9
MOLECULAR FORMULA : C4-H4-N2-S3
MOLECULAR WEIGHT : 176.28
WISWESSER LINE NOTATION : T55 ANYSS FN EU&TJ BUS
COMPOUND DESCRIPTOR : Agricultural Chemical
Mutagen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* 5,6-Dihydro-3H-imidazo(2,1-c)-1,2,4-dithiazole-3-thione
* Endodan
* ETEM
* Ethylene bisthiuram monosulfide
* Ethylenethiocarbamyl sulfide
* Ethylene thiuram monosulfide
* Ethylene thiuram monosulphide
* Ethylenethiuram sulfide
* ETM (heterocycle)
* Hortocritt
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 380 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ATSUDG Archives of Toxicology, Supplement. (Springer-Verlag New York, Inc.,
Service Center, 44 Hartz Way, Secaucus, NJ 07094) No.1- 1978-
Volume(issue)/page/year: 4,459,1980
** REPRODUCTIVE DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 304 mg/kg
SEX/DURATION : female 16 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - female fertility index (e.g. # females pregnant
per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
JHEMA2 Journal of Hygiene, Epidemiology, Microbiology, and Immunology.
(Avicenum, Malostranske namesti 28, 11802 Prague 1, Czechoslovakia) V.1-
1957- Volume(issue)/page/year: 24,295,1980
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 304 mg/kg
SEX/DURATION : male 16 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - male fertility index (e.g. # males impregnating
females per # males exposed to fertile nonpregnant females)
REFERENCE :
JHEMA2 Journal of Hygiene, Epidemiology, Microbiology, and Immunology.
(Avicenum, Malostranske namesti 28, 11802 Prague 1, Czechoslovakia) V.1-
1957- Volume(issue)/page/year: 24,295,1980
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 735 mg/kg
SEX/DURATION : female 1-21 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - delayed effects
REFERENCE :
PRKHDK Problemi na Khigienata. Problems in Hygiene. (Durzhavno
Izdatel'stvo Meditsina i Fizkultura, Pl. Slaveikov 11, Sofia, Bulgaria) V.1-
1975- Volume(issue)/page/year: 9,88,1984
** MUTATION DATA **
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 7500 ng/plate
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 157,13,1985
TYPE OF TEST : DNA repair
TEST SYSTEM : Bacteria - Bacillus subtilis
DOSE/DURATION : 2 ug/disc
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 40,19,1976
TYPE OF TEST : Sister chromatid exchange
TEST SYSTEM : Human Lymphocyte
DOSE/DURATION : 20 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 157,13,1985
TYPE OF TEST : Cytogenetic analysis
ROUTE OF EXPOSURE : Oral
TEST SYSTEM : Rodent - hamster
DOSE/DURATION : 93 mg/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 157,13,1985
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: B subtilis rec assay
*** END OF RECORD ***