RTECS NUMBER-NI3505000-Chemical Toxicity Database

                     *** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : NI3505000
CHEMICAL NAME           : Imidazole, 4-aminoethyl-, hydrochloride
CAS REGISTRY NUMBER     : 55-36-7
LAST UPDATED            : 199706
DATA ITEMS CITED        : 16
MOLECULAR FORMULA       : C5-H9-N3.xCl-H
MOLECULAR WEIGHT        : 366.39
WISWESSER LINE NOTATION : T5M CNJ D2Z &GH
COMPOUND DESCRIPTOR     : Tumorigen
SYNONYMS/TRADE NAMES :
   * Chlorhydrate d'histamine
   * Histamine, monohydrochloride
   * 1H-Imidazole-4-ethanamine, monohydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 230 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   ZIETA2 Zeitschrift fuer Immunitaetsforschung und Experimentelle Therapie.
   (Stuttgart, Fed. Rep. Ger.)  1924-62.  For publisher information, see
   ZIEKBA.  Volume(issue)/page/year: 60,222,1929
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ZIETA2 Zeitschrift fuer Immunitaetsforschung und Experimentelle Therapie.
   (Stuttgart, Fed. Rep. Ger.)  1924-62.  For publisher information, see
   ZIEKBA.  Volume(issue)/page/year: 60,222,1929
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1875 mg/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - spastic paralysis with or without sensory
   change
   Behavioral - tremor
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   ZIETA2 Zeitschrift fuer Immunitaetsforschung und Experimentelle Therapie.
   (Stuttgart, Fed. Rep. Ger.)  1924-62.  For publisher information, see
   ZIEKBA.  Volume(issue)/page/year: 60,222,1929
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 250 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   ZIETA2 Zeitschrift fuer Immunitaetsforschung und Experimentelle Therapie.
   (Stuttgart, Fed. Rep. Ger.)  1924-62.  For publisher information, see
   ZIEKBA.  Volume(issue)/page/year: 60,222,1929
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 3 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ZIETA2 Zeitschrift fuer Immunitaetsforschung und Experimentelle Therapie.
   (Stuttgart, Fed. Rep. Ger.)  1924-62.  For publisher information, see
   ZIEKBA.  Volume(issue)/page/year: 60,222,1929
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 1 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ZIETA2 Zeitschrift fuer Immunitaetsforschung und Experimentelle Therapie.
   (Stuttgart, Fed. Rep. Ger.)  1924-62.  For publisher information, see
   ZIEKBA.  Volume(issue)/page/year: 60,222,1929
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 12 mg/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   ZIETA2 Zeitschrift fuer Immunitaetsforschung und Experimentelle Therapie.
   (Stuttgart, Fed. Rep. Ger.)  1924-62.  For publisher information, see
   ZIEKBA.  Volume(issue)/page/year: 60,222,1929
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 10 mg/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   ZIETA2 Zeitschrift fuer Immunitaetsforschung und Experimentelle Therapie.
   (Stuttgart, Fed. Rep. Ger.)  1924-62.  For publisher information, see
   ZIEKBA.  Volume(issue)/page/year: 60,222,1929
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 300 ug/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   ZIETA2 Zeitschrift fuer Immunitaetsforschung und Experimentelle Therapie.
   (Stuttgart, Fed. Rep. Ger.)  1924-62.  For publisher information, see
   ZIEKBA.  Volume(issue)/page/year: 60,222,1929
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intracerebral
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 865 ug/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   ZIETA2 Zeitschrift fuer Immunitaetsforschung und Experimentelle Therapie.
   (Stuttgart, Fed. Rep. Ger.)  1924-62.  For publisher information, see
   ZIEKBA.  Volume(issue)/page/year: 60,222,1929
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraarterial
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 170 ug/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   ZIETA2 Zeitschrift fuer Immunitaetsforschung und Experimentelle Therapie.
   (Stuttgart, Fed. Rep. Ger.)  1924-62.  For publisher information, see
   ZIEKBA.  Volume(issue)/page/year: 60,222,1929
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Bird - pigeon
DOSE/DURATION           : 1498 ug/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   ZIETA2 Zeitschrift fuer Immunitaetsforschung und Experimentelle Therapie.
   (Stuttgart, Fed. Rep. Ger.)  1924-62.  For publisher information, see
   ZIEKBA.  Volume(issue)/page/year: 60,222,1929
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Amphibian - frog
DOSE/DURATION           : 1364 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ZIETA2 Zeitschrift fuer Immunitaetsforschung und Experimentelle Therapie.
   (Stuttgart, Fed. Rep. Ger.)  1924-62.  For publisher information, see
   ZIEKBA.  Volume(issue)/page/year: 60,222,1929
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Amphibian - frog
DOSE/DURATION           : 1700 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ZIETA2 Zeitschrift fuer Immunitaetsforschung und Experimentelle Therapie.
   (Stuttgart, Fed. Rep. Ger.)  1924-62.  For publisher information, see
   ZIEKBA.  Volume(issue)/page/year: 60,222,1929
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Parenteral
SPECIES OBSERVED        : Amphibian - frog
DOSE/DURATION           : 2273 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ZIETA2 Zeitschrift fuer Immunitaetsforschung und Experimentelle Therapie.
   (Stuttgart, Fed. Rep. Ger.)  1924-62.  For publisher information, see
   ZIEKBA.  Volume(issue)/page/year: 60,222,1929
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1140 mg/kg/28W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Gastrointestinal - tumors
REFERENCE :
   BAFEAG Bulletin de l'Association Francaise pour l'Etude du Cancer.  (Paris,
   France)  V.1-52, 1908-65. For publisher information, see BUCABS.
   Volume(issue)/page/year: 36,305,1949
 
                            *** END OF RECORD ***