*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : NI4021500 CHEMICAL NAME : Imidazole-5-carboxylic acid, 1-(alpha-methylbenzyl)-, ethyl ester, (R)-(+)- CAS REGISTRY NUMBER : 33125-97-2 BEILSTEIN REFERENCE NO. : 0665833 REFERENCE : 5-25-04-00085 (Beilstein Handbook Reference) LAST UPDATED : 199706 DATA ITEMS CITED : 5 MOLECULAR FORMULA : C14-H16-N2-O2 MOLECULAR WEIGHT : 244.32 COMPOUND DESCRIPTOR : Human SYNONYMS/TRADE NAMES : * Amidate * Amidate (pharmaceutical) * R-(+)-Ethyl 1-(1-phenylethyl)-1H-imidazole-5-carboxylate * Etomidate * (+)-Etomidate * (d)-Etomidate * Hypnomidate * 1H-Imidazole-5-carboxylic acid, 1-(1-phenylethyl)-, ethyl ester, (R)- * (R)-(+)-1-(alpha-Methylbenzyl)imidazole-5-carboxylic acid ethyl ester * 1-(alpha-Methylbenzyl)-1H-imidazole-5-carboxylic acid ethyl ester * 1-(1-Phenylethyl)-1H-imidazole-5-carboxylic acid ethyl ester * R 16659 *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Human DOSE/DURATION : 300 ug/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - other changes REFERENCE : AACRAT Anesthesia and Analgesia (New York). (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.36- 1957- Volume(issue)/page/year: 55,730,1976 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Human - man DOSE/DURATION : 3977 ug/kg/3H-C TOXIC EFFECTS : Behavioral - muscle contraction or spasticity REFERENCE : AACRAT Anesthesia and Analgesia (New York). (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.36- 1957- Volume(issue)/page/year: 64,80,1985 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 14800 ug/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 214,92,1975 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 650 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 65(1),19S,1969 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 29500 ug/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - ataxia REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 214,92,1975 *** END OF RECORD ***