*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : NI3355000
CHEMICAL NAME           : Imidazole-1-acetamide, N-(2-hydroxyethyl)-2-nitro-
CAS REGISTRY NUMBER     : 22668-01-5
OTHER CAS REGISTRY NOS. : 74083-16-2
BEILSTEIN REFERENCE NO. : 0919296
REFERENCE               : 5-23-04-00478 (Beilstein Handbook Reference)
LAST UPDATED            : 199612
DATA ITEMS CITED        : 6
MOLECULAR FORMULA       : C7-H10-N4-O4
MOLECULAR WEIGHT        : 214.21
WISWESSER LINE NOTATION : T5N CNJ A1VM2Q BNW
COMPOUND DESCRIPTOR     : Mutagen
SYNONYMS/TRADE NAMES :
   * N-(2-Hydroxyethyl)-2-nitro-1H-imidazole-1-acetamide
   * N-(2-Hydroxyethyl)-1-(2-nitro-1-imidazolyl)acetamide
   * 1H-Imidazole-1-acetamide, N-(2-hydroxyethyl)-2-nitro-
   * NSC 301467
   * SR 2508
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 3716 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Musculoskeletal - other changes
   Biochemical - Enzyme inhibition, induction, or change in blood or tissue
   levels - transaminases
REFERENCE :
   TOXID9 Toxicologist.  (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway,
   Akron, OH 44311) V.1-    1981-  Volume(issue)/page/year: 3,153,1983
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 3300 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   RAREAE Radiation Research.  (Academic Press, Inc., 1 E. First St., Duluth,
   MN 55802)  V.1-    1954-  Volume(issue)/page/year: 91,186,1982
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 4100 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JJCREP Japanese Journal of Cancer Research. (Elsevier Science Pub. BV, POB
   211, 1000 AE Amsterdam, Netherlands)  V.76-    1985-
   Volume(issue)/page/year: 80,113,1989
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 4900 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   USXXAM United States Patent Document.  (U.S. Patent Office, Box 9,
   Washington, DC 20231)  Volume(issue)/page/year: #4371540
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Mammal - species unspecified
DOSE/DURATION           : 4900 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GTKRDX Gan to Kagaku Ryoho.  Cancer and Chemotherapy.  (1-8-9 Yaesu,
   Chuo-ku, Tokyo 103, Japan) V.1-    1974-  Volume(issue)/page/year:
   16,1399,1989
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Morphological transformation
TEST SYSTEM             : Rodent - mouse Embryo
DOSE/DURATION           : 1 mmol/L/3D (Continuous)
REFERENCE :
   45OJAG "Radiation Sensitizers: Their Use in the Clinical Management of
   Cancer, Proceedings of the Conference, Key Biscayne, FL, 1979," Brady, L.W.,
   ed., New York, Masson Pub. USA, Inc., 1980  Volume(issue)/page/year:
   -,146,1980
 
                            *** END OF RECORD ***