*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : NJ0700000
CHEMICAL NAME           : 2-Imidazolidinone,
                          1-(2-hydroxyethyl)-3-((5-nitrofurfurylidene)amino)-
CAS REGISTRY NUMBER     : 5036-03-3
BEILSTEIN REFERENCE NO. : 0765002
REFERENCE               : 5-24-01-00162 (Beilstein Handbook Reference)
LAST UPDATED            : 199712
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C10-H12-N4-O5
MOLECULAR WEIGHT        : 268.26
WISWESSER LINE NOTATION : T5OJ BNW E1UN- AT5NVNTJ C2Q
COMPOUND DESCRIPTOR     : Tumorigen
                          Mutagen
SYNONYMS/TRADE NAMES :
   * Edrofuradene
   * 1-(2-Hydroxyethyl)-3-((5-nitrofurfurylidene)amino)-2-imidazolidinone
   * 2-Imidazolidinone,  
   1-(2-hydroxyethyl)-3-(((5-nitro-2-furanyl)methylene)amino)-
   * NF 1010
   * Nifurdazil
 
                       *** HEALTH HAZARD DATA ***
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 27 gm/kg/46W-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Kidney, Ureter, Bladder - Kidney tumors
   Skin and Appendages - tumors
REFERENCE :
   JNCIAM Journal of the National Cancer Institute.  (Washington, DC)  V.1-60,
   1940-78.  For publisher information, see JJIND8.  Volume(issue)/page/year:
   51,403,1973
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 100 ng/plate
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 48,295,1977

                              *** REVIEWS ***
 
   TOXICOLOGY REVIEW
   CCSUDL Carcinogenesis--A Comprehensive Survey.  (Raven Press, 1185 Ave. of
   the Americas, New York, NY 10036)  V.1-    1976-  Volume(issue)/page/year:
   4,171,1978

                          *** STATUS IN U.S. ***
 
   EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test

 
                            *** END OF RECORD ***