*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : NJ0775300
CHEMICAL NAME           : 4-Imidazolidinone,
                          5-(2-methylpropyl)-3-(2-propenyl)-2-thioxo-
CAS REGISTRY NUMBER     : 830-89-7
BEILSTEIN REFERENCE NO. : 0163719
REFERENCE               : 4-24-00-01139 (Beilstein Handbook Reference)
LAST UPDATED            : 199612
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C10-H16-N2-O-S
MOLECULAR WEIGHT        : 212.34
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Albutoin
   * BAX 422 Z
   * Coord
   * Euprax
   * Hydantoin, 3-allyl-5-isobutyl-2-thio-
   * 5-(2-Methylpropyl)-3-(2-propenyl)-2-thioxo-4-imidazolidinone
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 785 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   3,107,1961
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 294 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   3,107,1961
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 500 mg/kg/10D-I
TOXIC EFFECTS :
   Endocrine - evidence of thyroid hypofunction
   Endocrine - changes in thyroid weight
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   3,107,1961
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 10200 mg/kg/17D-I
TOXIC EFFECTS :
   Behavioral - tolerance
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   3,107,1961
 
                            *** END OF RECORD ***