*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : NJ0950000
CHEMICAL NAME           : 2-Imidazolidinone, 1-nitroso-
CAS REGISTRY NUMBER     : 3844-63-1
BEILSTEIN REFERENCE NO. : 0123509
REFERENCE               : 5-24-01-00162 (Beilstein Handbook Reference)
LAST UPDATED            : 199612
DATA ITEMS CITED        : 12
MOLECULAR FORMULA       : C3-H5-N3-O2
MOLECULAR WEIGHT        : 115.11
WISWESSER LINE NOTATION : T5MVNTJ CNO
COMPOUND DESCRIPTOR     : Tumorigen
                          Mutagen
SYNONYMS/TRADE NAMES :
   * Ethylenenitrosourea
   * Imidazolidinone, 1-nitroso-
   * 1-Nitroso-2-imidazolidinone
   * N-Nitroso-imidazolidon
   * N-Nitrosoimidazolidone
   * N-Nitroso-2-imidazolidone
   * 1-Nitroso-2-imidazolidone
   * NSC 73438
   * SRI 1869
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 250 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ZEKBAI Zeitschrift fuer Krebsforschung.  (Berlin, Fed. Rep. Ger.)  V.1-75,
   1903-71.  For publisher information, see JCROD7.  Volume(issue)/page/year:
   69,103,1967
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 28200 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NCISP* National Cancer Institute Screening Program Data Summary,
   Developmental Therapeutics Program. (Bethesda, MD 20205)
   Volume(issue)/page/year: JAN1986
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 600 mg/kg/20W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Lungs, Thorax, or Respiration - tumors
   Tumorigenic - tumors at site of application
REFERENCE :
   ZEKBAI Zeitschrift fuer Krebsforschung.  (Berlin, Fed. Rep. Ger.)  V.1-75,
   1903-71.  For publisher information, see JCROD7.  Volume(issue)/page/year:
   69,103,1967
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 16 umol/L/48H
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 48,131,1977
 
TYPE OF TEST            : Phage inhibition capacity
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 20 mg/L
REFERENCE :
   APMBAY Applied Microbiology.  (Washington, DC)  V.1-30, 1953-75.  For
   publisher information, see AEMIDF.  Volume(issue)/page/year: 23,91,1972
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Yeast - Saccharomyces cerevisiae
DOSE/DURATION           : 400 mg/L/30M
REFERENCE :
   GENTAE Genetics.  (Genetics Business Office, POB 64025, Baltimore, MD 21264)
    V.1-    1916-  Volume(issue)/page/year: 78,1101,1974
 
TYPE OF TEST            : Gene conversion and mitotic recombination
TEST SYSTEM             : Yeast - Saccharomyces cerevisiae
DOSE/DURATION           : 5 mmol/L
REFERENCE :
   ZEVBA5 Zeitschrift fuer Vererbungslehre.  (Berlin, Fed. Rep. Ger.) V.89-98,
   1958-66.  For publisher information, see MGGEAE. Volume(issue)/page/year:
   98,230,1966
 
TYPE OF TEST            : DNA damage
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - rat
DOSE/DURATION           : 310 ug/kg
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   47,3485,1987

                          *** STATUS IN U.S. ***
 
   EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test
   
   EPA GENETOX PROGRAM 1988, Positive: S cerevisiae gene conversion
   
   EPA GENETOX PROGRAM 1988, Positive: S cerevisiae-forward mutation; S
   cerevisiae-homozygosis
   
   EPA GENETOX PROGRAM 1988, Positive: S cerevisiae-reversion

 
                            *** END OF RECORD ***