*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : NJ2350000
CHEMICAL NAME           : 2-Imidazoline, 2-benzyl-, monohydrochloride
CAS REGISTRY NUMBER     : 59-97-2
LAST UPDATED            : 199701
DATA ITEMS CITED        : 10
MOLECULAR FORMULA       : C10-H12-N2.Cl-H
MOLECULAR WEIGHT        : 196.70
WISWESSER LINE NOTATION : T5M CN BUTJ B1R &GH
COMPOUND DESCRIPTOR     : Drug
                          Human
SYNONYMS/TRADE NAMES :
   * Arterodyl
   * Benzazoline hydrochloride
   * Benzylimidazoline hydrochloride
   * 2-Benzyl-2-imidazoline monohydrochloride
   * Cloridrato di 2-benzil-4,5-imidazolina
   * Imidaline hydrochloride
   * 1H-Imidazole, 4,5-dihydro-2-(phenylmethyl)-, monohydrochloride
   * 2-Imidazoline, 2-benzyl-, hydrochloride
   * Priscoline hydrochloride
   * Tolavad
   * Tolazoline chloride
   * Tolazoline hydrochloride
   * Tolpal
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Human - infant
DOSE/DURATION           : 48 mg/kg/47H-C
TOXIC EFFECTS :
   Gastrointestinal - ulceration or bleeding from duodenum
   Gastrointestinal - ulceration or bleeding from small intestine
REFERENCE :
   AUPJB7 Australian Paediatric Journal.  (Royal Childrens Hospital, Parkville,
   Vic., Australia) V.1-    1965-  Volume(issue)/page/year: 22,221,1986
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Human
DOSE/DURATION           : 150 ug/kg
TOXIC EFFECTS :
   Cardiac - change in rate
   Vascular - other changes
   Skin and Appendages - sweating
REFERENCE :
   FOMDAK Folia Medica (Naples).  (Naples, Italy)  V.1-57, 1915-74.
   Volume(issue)/page/year: 27,729,1941
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,511,1982
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 100 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,511,1982
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 85 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,511,1982
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 400 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - changes in motor activity (specific assay)
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 21,1992,1971
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 130 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - changes in motor activity (specific assay)
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 21,1992,1971
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 56700 ug/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - spastic paralysis with or without sensory
   change
   Behavioral - somnolence (general depressed activity)
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   JOPHDQ Journal of Pharmacobio-Dynamics.  (Japan Pub. Trading Co. (USA), 1255
   Howard St., San Francisco, CA 94103)  V.1-    1978- Volume(issue)/page/year:
   9,395,1986

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - X5567
       No. of Facilities: 41 (estimated)
       No. of Industries: 1
       No. of Occupations: 3
       No. of Employees: 2093 (estimated)
       No. of Female Employees: 1417 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA TSCA Section 8(b) CHEMICAL INVENTORY

 
                            *** END OF RECORD ***