*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : NJ2441000 CHEMICAL NAME : 4-Imidazoline-1-carboxylic acid, 3-methyl-2-thioxo-, ethyl ester CAS REGISTRY NUMBER : 22232-54-8 BEILSTEIN REFERENCE NO. : 0144339 REFERENCE : 4-24-00-00064 (Beilstein Handbook Reference) LAST UPDATED : 199612 DATA ITEMS CITED : 5 MOLECULAR FORMULA : C7-H10-N2-O2-S MOLECULAR WEIGHT : 186.25 COMPOUND DESCRIPTOR : Drug Mutagen Human SYNONYMS/TRADE NAMES : * Athyromazole * Basolest * Carbethoxymethimazole * Carbimazol * Carbimazole * CG1 * 1H-Imidazole-1-carboxylic acid, 2,3-dihydro-3-methyl-2-thioxo, ethyl ester * 3-Methyl-2-thioxo-4-imidazoline-1-carboxylic acid ethyl ester * Neomercazole * Tyrazol *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - woman DOSE/DURATION : 703 mg/kg/17W-I TOXIC EFFECTS : Sense Organs and Special Senses (Ear) - change in acuity Sense Organs and Special Senses (Ear) - tinnitus REFERENCE : BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year: 309,929,1994 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - woman DOSE/DURATION : 25 mg/kg/6W-I TOXIC EFFECTS : Liver - hepatitis (hepatocellular necrosis), diffuse REFERENCE : AIMDAP Archives of Internal Medicine. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1908- Volume(issue)/page/year: 145,1513,1985 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - man DOSE/DURATION : 23 mg/kg/5W-I TOXIC EFFECTS : Liver - jaundice, cholestatic REFERENCE : JRSMD9 Journal of the Royal Society of Medicine. (Oxford Univ. Press, Walton St., Oxford OX2 6DP, UK) V.71- 1978- Volume(issue)/page/year: 78,75,1985 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Parenteral SPECIES OBSERVED : Human - woman DOSE/DURATION : 1 mg/kg/1D-I TOXIC EFFECTS : Liver - jaundice, other or unclassified REFERENCE : NEJMAG New England Journal of Medicine. (Massachusetts Medical Soc., 10 Shattuck St., Boston, MA 02115) V.198- 1928- Volume(issue)/page/year: 309,438,1983 ** MUTATION DATA ** TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Yeast - Saccharomyces cerevisiae DOSE/DURATION : 1 gm/L REFERENCE : CHINAG Chemistry and Industry (London). (Royal Soc. of Chemistry, Distribution Centre, Blackhorse Rd., Letchworth, Herts SG6 1HN, UK) V.1- 1923- Volume(issue)/page/year: (21),847,1980 *** END OF RECORD ***