*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : NJ2465000
CHEMICAL NAME           : 2-Imidazoline,
                          2-((2-chloro-4-methyl-3-thienyl)amino)-,
                          monohydrochloride
CAS REGISTRY NUMBER     : 51274-83-0
OTHER CAS REGISTRY NOS. : 31428-62-3
LAST UPDATED            : 199109
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C8-H10-Cl-N3-S.Cl-H
MOLECULAR WEIGHT        : 252.18
WISWESSER LINE NOTATION : T5SJ BG D1 CM- BT5M CN BUTJ &GH
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * 2-(2'-Chloro-4'-methyl-3'-thienylamino)-1,3-diazacyclo-pent-2-ene  
   hydrochloride
   * 2-((2-Chloro-4-methyl-3-thienyl)amino)-2-imidazoline hydrochloride
   * N-(2-Chloro-4-methyl-3-thienyl)-4,5-dihydro-1H-imidazol-2-amine  
   hydrochloride
   * HOE 440
   * Sundralen
   * Symcor
   * Thiamenidine hydrochloride
   * Tiamenidine
   * Tiamenidine hydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 40 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - effect, not otherwise specified
   Autonomic Nervous System - sympathomimetic
   Skin and Appendages - hair
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 211,305,1974
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 400 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - effect, not otherwise specified
   Autonomic Nervous System - sympathomimetic
   Skin and Appendages - hair
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 211,305,1974
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 170 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - effect, not otherwise specified
   Autonomic Nervous System - sympathomimetic
   Skin and Appendages - hair
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 211,305,1974
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 45 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - effect, not otherwise specified
   Autonomic Nervous System - sympathomimetic
   Skin and Appendages - hair
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 211,305,1974
 
                            *** END OF RECORD ***