*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : NJ5099400 CHEMICAL NAME : 1H-Imidazo(1,2-c)pyrazolo(3,4-e)pyrimidine, 5-ethyl-1,3,8-trimethyl- CAS REGISTRY NUMBER : 89239-93-0 LAST UPDATED : 199706 DATA ITEMS CITED : 1 MOLECULAR FORMULA : C12-H14-N5 MOLECULAR WEIGHT : 228.31 COMPOUND DESCRIPTOR : Drug SYNONYMS/TRADE NAMES : * 5-Ethyl-1,3,8-trimethyl-1H-imidazo(1,2-c)pyrazolo(3,4-e)pyrimidine * PD 112488 *** HEALTH HAZARD DATA *** ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 350 mg/kg/14D-C TOXIC EFFECTS : Kidney, Ureter, Bladder - structural or functional changes in ureter Kidney, Ureter, Bladder - changes in bladder weight Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) REFERENCE : TOPADD Toxicologic Pathology. (c/o Dr. F.A. de la Iglesia, Warner-Lambert Co., Pharmaceutical Research Div., POB 1047, Ann Arbor, MI 48106) V.6(3/4)- 1978- Volume(issue)/page/year: 22,39,1994 *** END OF RECORD ***