*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : NJ5927000
CHEMICAL NAME           : Imidazo(5,1-d)-1,2,3,5-tetrazine-8-carboxamide,
                          3-(2-chloroethyl)-3,4-dihydro-4-oxo-
CAS REGISTRY NUMBER     : 85622-95-3
BEILSTEIN REFERENCE NO. : 3618072
LAST UPDATED            : 199612
DATA ITEMS CITED        : 5
MOLECULAR FORMULA       : C7-H7-Cl-N6-O2
MOLECULAR WEIGHT        : 242.65
COMPOUND DESCRIPTOR     : Drug
                          Mutagen
                          Reproductive Effector
                          Human
SYNONYMS/TRADE NAMES :
   * Azolastone
   * 8-Carbamoyl-3-(2-chloroethyl)imidazo(5,1-d)-1,2,3,5-tetrazin-4(3H)-one
   * CCRG 81010
   *   3-(2-Chloroethyl)-3,4-dihydro-4-oxoimidazo(5,1-d)-1,2,3,5-tetrazine-8-ca
     rboxamide
   * M & B 39565
   * Mitozolomide
   * NSC 353451
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human
DOSE/DURATION           : 3108 ug/kg
TOXIC EFFECTS :
   Gastrointestinal - nausea or vomiting
   Blood - changes in bone marrow (not otherwise specified)
REFERENCE :
   BJCAAI British Journal of Cancer.  (Macmillan Press Ltd., Houndmills,
   Basingstoke, Hants. RG21 2XS, UK)  V.1-    1947-  Volume(issue)/page/year:
   55,433,1987
 
TYPE OF TEST            : LD10 - Lethal Dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 45 mg/kg
TOXIC EFFECTS :
   Blood - changes in cell count (unspecified)
   Blood - changes in bone marrow (not otherwise specified)
   Tumorigenic - active as anti-cancer agent
REFERENCE :
   BJCAAI British Journal of Cancer.  (Macmillan Press Ltd., Houndmills,
   Basingstoke, Hants. RG21 2XS, UK)  V.1-    1947-  Volume(issue)/page/year:
   58,139,1988
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 40 mg/kg
SEX/DURATION            : male 1 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,
   sperm morphology, motility, and count)
REFERENCE :
   ATSUDG Archives of Toxicology, Supplement.  (Springer-Verlag New York, Inc.,
   Service Center, 44 Hartz Way, Secaucus, NJ 07094)  No.1-    1978-
   Volume(issue)/page/year: 11,273,1987
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : DNA damage
TEST SYSTEM             : Human Embryo
DOSE/DURATION           : 50 umol/L
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   44,1772,1984
 
TYPE OF TEST            : DNA damage
TEST SYSTEM             : Rodent - mouse Leukocyte
DOSE/DURATION           : 50 umol/L
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   44,1767,1984
 
                            *** END OF RECORD ***