*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : NJ5950000
CHEMICAL NAME           : Imidazo(2,1-b)thiazole, 2,3,5,6-tetrahydro-6-phenyl-,
                          monohydrochloride, (+-)-
CAS REGISTRY NUMBER     : 5086-74-8
LAST UPDATED            : 199306
DATA ITEMS CITED        : 9
MOLECULAR FORMULA       : C11-H12-N2-S.Cl-H
MOLECULAR WEIGHT        : 240.77
WISWESSER LINE NOTATION : T55 AN DN FS DUTJ CR &GH -R
COMPOUND DESCRIPTOR     : Human
SYNONYMS/TRADE NAMES :
   * Anthelvet
   * (+-)-Anthelvet
   * Bayer 9051
   * Citarin
   * McN-JR-8299
   * Nilverm
   * Nilverom
   * Orovermol
   * DL-6-Phenyl-2,3,5,6-tetrahydroimidazole(2,1-b)thiazole-hydrochloride
   * R 8299
   * Ripercol
   * Ripereol
   * Spartakon
   * (+-)-2,3,5,6-Tetrahydro-6-phenylimidazo(2,1-b)thiazole monohydrochloride
   * Tetramisole
   * Tetramisole hydrochloride
   * DL-Tetramisole hydrochloride
   * Tetramisol hydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human
DOSE/DURATION           : 2 mg/kg
TOXIC EFFECTS :
   Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   20,602,1971
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 480 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   NATUAS Nature.  (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736)
   V.1-    1869-  Volume(issue)/page/year: 209,1084,1966
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 130 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   NATUAS Nature.  (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736)
   V.1-    1869-  Volume(issue)/page/year: 209,1084,1966
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 24 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   NATUAS Nature.  (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736)
   V.1-    1869-  Volume(issue)/page/year: 209,1084,1966
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 210 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   NATUAS Nature.  (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736)
   V.1-    1869-  Volume(issue)/page/year: 209,1084,1966
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 84 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   NATUAS Nature.  (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736)
   V.1-    1869-  Volume(issue)/page/year: 209,1084,1966
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 22 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   NATUAS Nature.  (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736)
   V.1-    1869-  Volume(issue)/page/year: 209,1084,1966
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Bird - duck
DOSE/DURATION           : 958 mg/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - flaccid paralysis without anesthesia
   (usually neuromuscular blockage)
REFERENCE :
   VETNAL Veterinariya.  Veterinary Science.  (V/O Mezhdunarodnaya Kniga,
   113095 Moscow, USSR) V.1-    1924-  Volume(issue)/page/year: 54(5),64,1978
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Mammal - cattle
DOSE/DURATION           : 450 mg/kg/5D-I
TOXIC EFFECTS :
   Related to Chronic Data - death
REFERENCE :
   AUVJA2 Australian Veterinary Journal.  (Australian Veterinary Assoc.,
   Executive Director, 134-136 Hampden Road, Artarmon, N.S.W., Australia) V.2- 
     1927-  Volume(issue)/page/year: 46,297,1970
 
                            *** END OF RECORD ***