*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : NJ8999500
CHEMICAL NAME           : Immunoglobulin G 1 (mouse monoclonal H65-RTA
                          anti-human antigen CD5 heavy chain), disulfide with
                          mouse monoclonal H65-rta light chain, dimer,
                          disulfide with ricin (castor oil plant A-chain
                          protein moiety)
CAS REGISTRY NUMBER     : 141483-72-9
LAST UPDATED            : 199603
DATA ITEMS CITED        : 3
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * H65-RTA
   * Monoclonal antibody (antitrombotic)
   * Orthzyme CD5plus
   * Zolimomab Aritox
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 60 mg/kg
TOXIC EFFECTS :
   Cardiac - other changes
   Kidney, Ureter, Bladder - other changes
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   FAATDF Fundamental and Applied Toxicology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1981-  Volume(issue)/page/year:
   26,75,1995
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 7 mg/kg/14D-I
TOXIC EFFECTS :
   Endocrine - changes in thymus weight
   Blood - changes in platelet count
   Biochemical - Metabolism (Intermediary) - other proteins
REFERENCE :
   FAATDF Fundamental and Applied Toxicology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1981-  Volume(issue)/page/year:
   26,75,1995
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Primate - monkey
DOSE/DURATION           : 2800 ug/kg/14D-I
TOXIC EFFECTS :
   Blood - pigmented or nucleated red blood cells
   Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
   Biochemical - Metabolism (Intermediary) - other proteins
REFERENCE :
   FAATDF Fundamental and Applied Toxicology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1981-  Volume(issue)/page/year:
   26,75,1995
 
                            *** END OF RECORD ***