*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : NK6125000
CHEMICAL NAME : 1,3-Indandione, 2-phenyl-
CAS REGISTRY NUMBER : 83-12-5
LAST UPDATED : 199512
DATA ITEMS CITED : 12
MOLECULAR FORMULA : C15-H10-O2
MOLECULAR WEIGHT : 222.25
WISWESSER LINE NOTATION : L56 BV DV CHJ CR
COMPOUND DESCRIPTOR : Drug
Human
SYNONYMS/TRADE NAMES :
* Athrombon
* Bindan
* Danilone
* Diadilan
* Dindevan
* Dineval
* Emandione
* Fenhydren
* Fenilin
* 2-Fenyloindandion-1,3
* Hedulin
* Indema
* 1H-Indene-1,3(2H)-dione, 2-phenyl-
* Indion
* Indon
* Phenhydren
* Phenindione
* 2-Phenyl-1,3-diketohydrindene
* Phenylen
* 2-Phenylindan-1,3-dione
* 2-Phenyl-1,3-indandione
* 2-Phenyl-1H-indene-1,3(2H)-dione
* Phenylindione
* Phenyline
* Phenyllin
* Pindione
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - man
DOSE/DURATION : 42500 ug/kg/17D-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - interstitial nephritis
Kidney, Ureter, Bladder - urine volume decreased
REFERENCE :
BMJOAE British Medical Journal. (British Medical Assoc., BMA House,
Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year:
1,1655,1963
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - man
DOSE/DURATION : 48 mg/kg/27D-I
TOXIC EFFECTS :
Blood - other changes
Nutritional and Gross Metabolic - body temperature increase
REFERENCE :
NZMJAX New Zealand Medical Journal. (New Zealand Medical Assoc., P.O. Box
156, Wellington, New Zealand) V.1- 1900- Volume(issue)/page/year:
57,283,1958
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Human - man
DOSE/DURATION : 22 mg/kg/17D-I
TOXIC EFFECTS :
Liver - hepatitis (hepatocellular necrosis), diffuse
Kidney, Ureter, Bladder - interstitial nephritis
Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
AIMEAS Annals of Internal Medicine. (American College of Physicians, 4200
Pine St., Philadelphia, PA 19104) V.1- 1927- Volume(issue)/page/year:
52,706,1960
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Human - man
DOSE/DURATION : 90 mg/kg/27D-I
TOXIC EFFECTS :
Liver - hepatitis (hepatocellular necrosis), diffuse
Skin and Appendages - dermatitis, allergic (after systemic exposure)
REFERENCE :
CMAJAX Canadian Medical Association Journal. (Canadian Medical Assoc., POB
8650, Ottawa, ON K1G 0G8, Canada) V.1- 1911- Volume(issue)/page/year:
77,1028,1957
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Human - man
DOSE/DURATION : 1683 mg/kg/31D-I
TOXIC EFFECTS :
Gastrointestinal - nausea or vomiting
Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
acute tubular necrosis)
Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823-
Volume(issue)/page/year: 1,920,1963
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 163 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique.
(Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France)
V.9- 1974- Volume(issue)/page/year: 9,519,1974
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 190 mg/kg
TOXIC EFFECTS :
Behavioral - rigidity (including catalepsy)
Behavioral - muscle contraction or spasticity
REFERENCE :
THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris,
France) V.1- 1946- Volume(issue)/page/year: 16,34,1961
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 175 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
SMWOAS Schweizerische Medizinische Wochenschrift. (Schwabe & Co.,
Steintorst 13, 4010 Basel, Switzerland) V.50- 1920-
Volume(issue)/page/year: 90,213,1960
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 150 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PHARAT Pharmazie. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18,
Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1946- Volume(issue)/page/year:
27,520,1972
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 140 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DIPHAH Dissertationes Pharmaceuticae. (Warsaw, Poland) V.1-17, 1949-65.
For publisher information, see PJPPAA. Volume(issue)/page/year: 8,289,1956
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 130 mg/kg
TOXIC EFFECTS :
Behavioral - rigidity (including catalepsy)
Behavioral - muscle contraction or spasticity
REFERENCE :
THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris,
France) V.1- 1946- Volume(issue)/page/year: 16,34,1961
*** REVIEWS ***
TOXICOLOGY REVIEW
AJMEAZ American Journal of Medicine. (Technical Pub., 875 Third Ave., New
York, NY 10022) V.1- 1946- Volume(issue)/page/year: 38,409,1965
*** END OF RECORD ***