*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : NK8350000
CHEMICAL NAME           : Indene, 1-(4-dimethylaminobenzylidene)-
CAS REGISTRY NUMBER     : 443-30-1
LAST UPDATED            : 199712
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C18-H17-N
MOLECULAR WEIGHT        : 247.36
WISWESSER LINE NOTATION : L56 BYJ BU1R DN1&1
COMPOUND DESCRIPTOR     : Tumorigen
SYNONYMS/TRADE NAMES :
   * Benzenamine, 4-(1H-inden-1-ylidenemethyl)-N,N-dimethyl-
   * DABI
   * 1-(4-Dimethylaminobenzal)indene
   * (4-Dimethylaminobenzylidene)indene
   * 4-(1H-Inden-1-ylidenemethyl)-N,N-dimethylbenzenamine
   * 1-(p-Methylaminobenzylidene)indene
   * NSC-80087
   * p-Toluidine, alpha-inden-1-ylidene-N,N-dimethyl-
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 13,771,1970
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 270 mg/kg/15D-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Skin and Appendages - tumors
   Reproductive - Tumorigenic effects - ovarian tumors
REFERENCE :
   NATUAS Nature.  (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736)
   V.1-    1869-  Volume(issue)/page/year: 222,383,1969
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 4000 mg/kg/26W-C
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Liver - tumors
REFERENCE :
   PTEUA6 Pathologia Europaea.  (Brussels, Belgium)  V.1-11, 1966-76.
   Discontinued.  Volume(issue)/page/year: 7,229,1972
 
                            *** END OF RECORD ***