*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : NK8927000
CHEMICAL NAME           : 5H-Indeno(5,6-d)-1,3-dioxole,
                          5-dimethylamino-6-propyl-, hydrochloride
CAS REGISTRY NUMBER     : 51003-81-7
LAST UPDATED            : 199606
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C15-H19-N-O2.Cl-H
MOLECULAR WEIGHT        : 281.81
WISWESSER LINE NOTATION : T C565 DO FO EH JHJ JN1&1 K3 &GH
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * 5-Dimethylamino-6-propyl-5H-indeno(5,6-d)-1,3-dioxole hydrochloride
   * N,N-Dimethyl-6-propyl-5H-indeno(5,6-d)-1,3-dioxol-5-amine hydrochloride
   * 5H-Indeno(5,6-d)-1,3-dioxol-5-amine, N,N-dimethyl-6-propyl-,  
   hydrochloride
   * pr-MDI
   * 2-Propyl-3-dimethylamino-5,6-methylenedioxyindene hydrochloride
   * 2-n-Propyl-3-dimethylamino-5,6-methylenedioxyindene hydrochloride
   * 2-Propyl-5,6-methylenedioxyindene-1-dimethylammonium hydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 175 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - changes in motor activity (specific assay)
   Gastrointestinal - decreased motility or constipation
REFERENCE :
   RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD
   Pub. Ltd., P.O. Box 966, Westbury, NY 11590)  V.1-    1970-
   Volume(issue)/page/year: 26,85,1979
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 185 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - changes in motor activity (specific assay)
   Gastrointestinal - decreased motility or constipation
REFERENCE :
   RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD
   Pub. Ltd., P.O. Box 966, Westbury, NY 11590)  V.1-    1970-
   Volume(issue)/page/year: 26,85,1979
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 40 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - changes in motor activity (specific assay)
   Gastrointestinal - decreased motility or constipation
REFERENCE :
   RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD
   Pub. Ltd., P.O. Box 966, Westbury, NY 11590)  V.1-    1970-
   Volume(issue)/page/year: 26,85,1979
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1470 mg/kg/4W-I
TOXIC EFFECTS :
   Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
   Biochemical - Enzyme inhibition, induction, or change in blood or tissue
   levels - dehydrogenases
REFERENCE :
   RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD
   Pub. Ltd., P.O. Box 966, Westbury, NY 11590)  V.1-    1970-
   Volume(issue)/page/year: 26,85,1979
 
                            *** END OF RECORD ***