*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : NK6825000
CHEMICAL NAME           : 1,3-Indandione, 2-(p-(trifluoromethyl)phenyl)-
CAS REGISTRY NUMBER     : 6723-40-6
BEILSTEIN REFERENCE NO. : 1888302
LAST UPDATED            : 199612
DATA ITEMS CITED        : 5
MOLECULAR FORMULA       : C16-H9-F3-O2
MOLECULAR WEIGHT        : 290.25
WISWESSER LINE NOTATION : L56 BV DV CHJ CR DXFFF
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * B.S. 7617-D
   * Fluindarol
   * 1,3-Indandione, 2-(alpha,alpha,alpha-trifluoro-p-tolyl)-
   * 2-(p-(Trifluoromethyl)phenyl)-1,3-indandi0NE
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 198 mg/kg
TOXIC EFFECTS :
   Blood - hemorrhage
   Liver - fatty liver degeneration
   Sense Organs and Special Senses (Eye) - visual field changes
REFERENCE :
   APTOA6 Acta Pharmacologica et Toxicologica.  (Copenhagen, Denmark)  V.1-59,
   1945-86.  For publisher information, see PHTOEH  Volume(issue)/page/year:
   28,425,1970
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 125 mg/kg
TOXIC EFFECTS :
   Blood - hemorrhage
   Liver - fatty liver degeneration
   Sense Organs and Special Senses (Eye) - visual field changes
REFERENCE :
   APTOA6 Acta Pharmacologica et Toxicologica.  (Copenhagen, Denmark)  V.1-59,
   1945-86.  For publisher information, see PHTOEH  Volume(issue)/page/year:
   28,425,1970
 
TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : >2810 mg/kg
TOXIC EFFECTS :
   Behavioral - food intake (animal)
   Gastrointestinal - nausea or vomiting
REFERENCE :
   APTOA6 Acta Pharmacologica et Toxicologica.  (Copenhagen, Denmark)  V.1-59,
   1945-86.  For publisher information, see PHTOEH  Volume(issue)/page/year:
   28,425,1970
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 123 mg/kg
TOXIC EFFECTS :
   Behavioral - food intake (animal)
   Gastrointestinal - nausea or vomiting
   Behavioral - somnolence (general depressed activity)
REFERENCE :
   APTOA6 Acta Pharmacologica et Toxicologica.  (Copenhagen, Denmark)  V.1-59,
   1945-86.  For publisher information, see PHTOEH  Volume(issue)/page/year:
   28,425,1970
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 756 mg/kg/28D-I
TOXIC EFFECTS :
   Blood - normocytic anemia
   Blood - pigmented or nucleated red blood cells
   Related to Chronic Data - death
REFERENCE :
   APTOA6 Acta Pharmacologica et Toxicologica.  (Copenhagen, Denmark)  V.1-59,
   1945-86.  For publisher information, see PHTOEH  Volume(issue)/page/year:
   28,425,1970
 
                            *** END OF RECORD ***