*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : NL4025000
CHEMICAL NAME           : Indole,
                          3-(2-aminoethyl)-1-benzyl-5-methoxy-2-methyl-,
                          monohydrochloride
CAS REGISTRY NUMBER     : 525-02-0
LAST UPDATED            : 199009
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C19-H22-N2-O.Cl-H
MOLECULAR WEIGHT        : 330.89
WISWESSER LINE NOTATION : T56 BNJ B1R& C1 D2Z GO1 &GH
COMPOUND DESCRIPTOR     : Drug
                          Reproductive Effector
SYNONYMS/TRADE NAMES :
   * 3-(2-Aminoethyl)-1-benzyl-5-methoxy-2-methylindole hydrochloride
   * BAS
   * Benanserin hydrochloride
   * Benzyl antiserotonin
   * 1-Benzyl-2,5-dimethylserotonin hydrochloride
   * 1-Benzyl-2-methyl-3-(2-aminoethyl)-5-methoxyindole hydrochloride
   * Benzyl-1 methyl-2 methoxy-5 tryptamine chlorhydrate
   * 1-Benzyl-2-methyl-5-methoxytryptamine hydrochloride
   * 5-Methoxy-2-methyl-1-(phenylmethyl)-1H-indole-3-ethanamide  
   monohydrochloride
   * Serotonin benzyl analog
   * Woolley's antiserotonin
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 250 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 9,819,1966
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 300 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   THERAP Therapie.  (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris,
   France)  V.1-    1946-  Volume(issue)/page/year: 18,833,1963
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 70 mg/kg
SEX/DURATION            : female 8-14 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - stillbirth
   Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
   gain)
   Reproductive - Effects on Newborn - behavioral
REFERENCE :
   PEDIAU Pediatrics.  (American Academy of Pediatrics, P.O. Box 1034,
   Evanston, IL 60204) V.1-    1948-  Volume(issue)/page/year: 27,318,1961
 
                            *** END OF RECORD ***