*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : NL7960000
CHEMICAL NAME           : Indole-2,3-dione, 1-methyl-, 3-(thiosemicarbazone)
CAS REGISTRY NUMBER     : 1910-68-5
LAST UPDATED            : 199106
DATA ITEMS CITED        : 5
MOLECULAR FORMULA       : C10-H10-N4-O-S
MOLECULAR WEIGHT        : 234.30
WISWESSER LINE NOTATION : T56 BNVYJ B1 DUNMYZUS
COMPOUND DESCRIPTOR     : Drug
                          Mutagen
SYNONYMS/TRADE NAMES :
   * BW 33-T-57
   * Compound 33T57
   * Hydrazinecarbothioamide,  
   2-(1,2-dihydro-1-methyl-2-oxo-3H-indole-3-ylidene)-
   * Kemoviran
   * Marboran
   * Methisazone
   * N-Methylindole-2,3-dione thiosemicarbazone
   * 1-Methylindole-2,3-dione 3-(thiosemicarbazone)
   * N-Methylisatin thiosemicarbazone
   * N-Methylisatin 3-(thiosemicarbazone)
   * Metisazon
   * Metisazone
   * Metisazonum
   * MIBT
   * NSC-69811
   * 33T57
   * Viruzona
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 4 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 22,1704,1972
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >50 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 22,1704,1972
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 56 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems
   Laboratory, NIOSH Exchange Chemicals.  (Aberdeen Proving Ground, MD 21010)
   Volume(issue)/page/year: NX#02255
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Microorganism - not otherwise specified
DOSE/DURATION           : 50 umol/L
REFERENCE :
   BBACAQ Biochimica et Biophysica Acta.  (Elsevier Science Pub. B.V., POB 211,
   1000 AE Amsterdam, Netherlands)  V.1-    1947- Volume(issue)/page/year:
   519,65,1978
 
TYPE OF TEST            : DNA damage
TEST SYSTEM             : Human HeLa cell
DOSE/DURATION           : 30 umol/L
REFERENCE :
   BCPCA6 Biochemical Pharmacology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.1-    1958-  Volume(issue)/page/year:
   25,821,1976
 
                            *** END OF RECORD ***