*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : AX7890000
CHEMICAL NAME           : Ajmalicine, hydrochloride
CAS REGISTRY NUMBER     : 4373-34-6
LAST UPDATED            : 199306
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C21-H24-N2-O3.Cl-H
MOLECULAR WEIGHT        : 388.93
WISWESSER LINE NOTATION : T F6 D5 C666 EM ON SO TU&&TTTJ R1 UVO1 &GH
SYNONYMS/TRADE NAMES :
   * Ajmalicine, monohydrochloride
   * Oxayohimban-16-carboxylic acid, 16,17-didehydro-19-methyl-, methyl ester, 
    monohydrochloride
   * Raubasine hydrochloride
   * gamma-Yohimbine hydrochloride
   * gamma-Yohimbin hydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 50 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   LDBU** "Zur Pharmakologie der Yohimbealkaloide, Dissertation," Langer, J.,
   Institute fuer Pharmakologie und Experimentelle Therapie der Universitat
   Breslau, Poland, 1932  Volume(issue)/page/year: -,-,1932
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 56 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems
   Laboratory, NIOSH Exchange Chemicals.  (Aberdeen Proving Ground, MD 21010)
   Volume(issue)/page/year: NX#00444
 
                            *** END OF RECORD ***