*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : AX8155800 CHEMICAL NAME : Ajmalanium, 17,21-dihydroxy-4-propyl-, (17R,21-alpha)- CAS REGISTRY NUMBER : 35080-11-6 LAST UPDATED : 198602 DATA ITEMS CITED : 3 MOLECULAR FORMULA : C23-H33-N2-O2 MOLECULAR WEIGHT : 369.58 COMPOUND DESCRIPTOR : Drug SYNONYMS/TRADE NAMES : * (17R,21-alpha)-17,21-Dihydroxy-4-propylajmalanium * Prajmaline * Prajmalium * N-Propylajmaline * N-Propylajmalinium * N(sup 4)-Propylajmalinium *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1400 ug/kg TOXIC EFFECTS : Cardiac - other changes REFERENCE : PHARAT Pharmazie. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1946- Volume(issue)/page/year: 31,36,1976 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 65500 ug/kg TOXIC EFFECTS : Behavioral - altered sleep time (including change in righting reflex) Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia REFERENCE : CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA, 1255 Howard St., San Francisco, CA 94103) V.6- 1958- Volume(issue)/page/year: 22,2329,1974 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 3400 ug/kg TOXIC EFFECTS : Behavioral - altered sleep time (including change in righting reflex) Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia REFERENCE : CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA, 1255 Howard St., San Francisco, CA 94103) V.6- 1958- Volume(issue)/page/year: 22,2329,1974 *** END OF RECORD ***