*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : AX8155800
CHEMICAL NAME           : Ajmalanium, 17,21-dihydroxy-4-propyl-,
                          (17R,21-alpha)-
CAS REGISTRY NUMBER     : 35080-11-6
LAST UPDATED            : 198602
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C23-H33-N2-O2
MOLECULAR WEIGHT        : 369.58
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * (17R,21-alpha)-17,21-Dihydroxy-4-propylajmalanium
   * Prajmaline
   * Prajmalium
   * N-Propylajmaline
   * N-Propylajmalinium
   * N(sup 4)-Propylajmalinium
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1400 ug/kg
TOXIC EFFECTS :
   Cardiac - other changes
REFERENCE :
   PHARAT Pharmazie.  (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18,
   Berlin DDR-1020, Ger. Dem. Rep.)  V.1-    1946-  Volume(issue)/page/year:
   31,36,1976
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 65500 ug/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - ataxia
REFERENCE :
   CPBTAL Chemical and Pharmaceutical Bulletin.  (Japan Pub. Trading Co., USA,
   1255 Howard St., San Francisco, CA 94103)  V.6-    1958-
   Volume(issue)/page/year: 22,2329,1974
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 3400 ug/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - ataxia
REFERENCE :
   CPBTAL Chemical and Pharmaceutical Bulletin.  (Japan Pub. Trading Co., USA,
   1255 Howard St., San Francisco, CA 94103)  V.6-    1958-
   Volume(issue)/page/year: 22,2329,1974
 
                            *** END OF RECORD ***