*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : AY3310000 CHEMICAL NAME : Alanine, 3-(o-((bis(2-chloroethyl)amino)methyl)phenyl)-, dihydrochloride CAS REGISTRY NUMBER : 2185-98-0 LAST UPDATED : 199412 DATA ITEMS CITED : 4 MOLECULAR FORMULA : C14-H20-Cl2-N2-O2.2Cl-H MOLECULAR WEIGHT : 392.18 WISWESSER LINE NOTATION : QVYZ1R B1N2G2G &GH &GH COMPOUND DESCRIPTOR : Drug SYNONYMS/TRADE NAMES : * Alanine, 3-(alpha-(bis(2-chloroethyl)amino)-o-tolyl)-, dihydrochloride * AT-581 * o-Bis(2-chloroethyl)aminomethylphenylalanine hydrochloride * 3-(o-((Bis(2-chloroethyl)amino)methyl)phenyl)alanine dihydrochloride * Ocaphane * Phenylalanine, 2-((bis(2-chloroethyl)amino)methyl)-, dihydrochloride *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 5500 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : CYLPDN Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. Chinese Journal of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1980- Volume(issue)/page/year: 2,121,1981 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 32 mg/kg TOXIC EFFECTS : Tumorigenic - active as anti-cancer agent REFERENCE : YHTPAD Yaoxue Tongbao. Bulletin of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.13-23, 1978-88. For publisher information, see ZYZAEU. Volume(issue)/page/year: 15(8),41,1980 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 4900 ug/kg TOXIC EFFECTS : Tumorigenic - active as anti-cancer agent REFERENCE : CYLPDN Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. Chinese Journal of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1980- Volume(issue)/page/year: 2,121,1981 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 2500 ug/kg/10D-I TOXIC EFFECTS : Blood - changes in leukocyte (WBC) count Blood - changes in platelet count Nutritional and Gross Metabolic - weight loss or decreased weight gain REFERENCE : CYLPDN Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. Chinese Journal of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1980- Volume(issue)/page/year: 2,121,1981 *** END OF RECORD ***