*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : AY3340000 CHEMICAL NAME : Alanine, 3-(p-(p-(bis(2-chloroethyl)amino)phenoxy)phenyl)-, DL- CAS REGISTRY NUMBER : 857-95-4 LAST UPDATED : 199807 DATA ITEMS CITED : 10 MOLECULAR FORMULA : C19-H22-Cl2-N2-O3 MOLECULAR WEIGHT : 397.33 WISWESSER LINE NOTATION : QVYZ1R DOR DN2G2G COMPOUND DESCRIPTOR : Mutagen SYNONYMS/TRADE NAMES : * O-(4-(Bis(2-chloroethyl)amino)phenyl)-DL-tyrosine * Fenitirin * Phentyrin * DL-Tyrosine, O-(4-(bis(2-chloroethyl)amino)phenyl)- *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 620 mg/kg TOXIC EFFECTS : Gastrointestinal - other changes Liver - other changes Kidney, Ureter, Bladder - other changes REFERENCE : FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 43,100,1980 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 115 mg/kg TOXIC EFFECTS : Gastrointestinal - other changes Liver - other changes Kidney, Ureter, Bladder - other changes REFERENCE : FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 43,100,1980 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 62 mg/kg TOXIC EFFECTS : Gastrointestinal - other changes Liver - other changes Kidney, Ureter, Bladder - other changes REFERENCE : FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 43,100,1980 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 360 mg/kg TOXIC EFFECTS : Gastrointestinal - other changes Liver - other changes Kidney, Ureter, Bladder - other changes REFERENCE : FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 43,100,1980 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 110 mg/kg TOXIC EFFECTS : Gastrointestinal - other changes Liver - other changes Kidney, Ureter, Bladder - other changes REFERENCE : FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 43,100,1980 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 30 mg/kg TOXIC EFFECTS : Gastrointestinal - other changes Liver - other changes Kidney, Ureter, Bladder - other changes REFERENCE : FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 43,100,1980 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 15 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 43,100,1980 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 120 mg/kg/10D-I TOXIC EFFECTS : Gastrointestinal - ulceration or bleeding from large intestine Blood - changes in bone marrow (not otherwise specified) Related to Chronic Data - death REFERENCE : FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 43,100,1980 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 6 mg/kg/10D-I TOXIC EFFECTS : Cardiac - EKG changes not diagnostic of specified effects Kidney, Ureter, Bladder - other changes Blood - changes in spleen REFERENCE : FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 43,100,1980 *** STATUS IN U.S. *** EPA GENETOX PROGRAM 1988, Positive: D melanogaster Sex-linked lethal *** END OF RECORD ***