*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : AY3400000
CHEMICAL NAME           : Alanine, 3-(o-(bis(2-chloroethyl)amino)phenyl)-, DL-
CAS REGISTRY NUMBER     : 342-95-0
LAST UPDATED            : 199203
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C13-H18-Cl2-N2-O2
MOLECULAR WEIGHT        : 305.23
WISWESSER LINE NOTATION : QVYZ1R BN2G2G
SYNONYMS/TRADE NAMES :
   * DL-Alanine, 3-(o-(bis(2-chloroethyl)amino)phenyl)-
   * 3-(o-(Bis(beta-chloroethyl)amino)phenyl)-D,L-alanine
   * CB 1729
   * o-Di-2-chloroethylamino-DL-phenylalanine
   * FDA 0109
   * Merophan
   * o-Merphalan
   * NSC-57199
   * Ortho-phenylalanine mustard
   * DL-Phenylalanine, 2-(bis(2-chloroethyl)amino)-
   * (+-)-O-Phenylalanine mustard
   * o-Phenylalanine mustard
   * o-DL-Sarcolysin
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 3510 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BCPCA6 Biochemical Pharmacology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.1-    1958-  Volume(issue)/page/year:
   13,969,1964
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 18480 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NCISP* National Cancer Institute Screening Program Data Summary,
   Developmental Therapeutics Program. (Bethesda, MD 20205)
   Volume(issue)/page/year: JAN1986
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 190 ug/kg
TOXIC EFFECTS :
   Blood - leukopenia
   Blood - thrombocytopenia
   Blood - other changes
REFERENCE :
   CCSUBJ Cancer Chemotherapy Reports, Part 2.  (Washington, DC)  V.1-5,
   1964-75.  For publisher information, see CTRRDO.  Volume(issue)/page/year:
   2,201,1965
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Primate - monkey
DOSE/DURATION           : 380 ug/kg
TOXIC EFFECTS :
   Blood - leukopenia
   Blood - other changes
REFERENCE :
   CCSUBJ Cancer Chemotherapy Reports, Part 2.  (Washington, DC)  V.1-5,
   1964-75.  For publisher information, see CTRRDO.  Volume(issue)/page/year:
   2,201,1965
 
                            *** END OF RECORD ***