*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : AU7481800
CHEMICAL NAME           : 5'-Adenylic acid, compd. with
                          1-((3,4-dimethoxyphenyl)methyl)-6,7-dimethoxyisoquino
                          line (1:1)
CAS REGISTRY NUMBER     : 39024-96-9
LAST UPDATED            : 198910
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C20-H21-N-O4.C10-H14-N5-O7-P
MOLECULAR WEIGHT        : 686.68
COMPOUND DESCRIPTOR     : Drug
                          Human
SYNONYMS/TRADE NAMES :
   * Dicertan
   * Monophosadenine de papaverine
   * Papaverine adenosine 5-monophosphate
   * Papaverine adenosine phosphate
   * Papaverine adenylate
   * Papaverine monophosadenine
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 17520 mg/kg/6Y-I
TOXIC EFFECTS :
   Liver - hepatitis, fibrous (cirrhosis, post-necrotic scarring)
   Liver - jaundice, other or unclassified
REFERENCE :
   GASTAB Gastroenterology.  (Academic Press, Inc., 1 E. First St., Duluth, MN
   55802)  V.1-    1943-  Volume(issue)/page/year: 90,1051,1986
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 3910 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - ptosis
   Behavioral - antipsychotic
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   THERAP Therapie.  (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris,
   France)  V.1-    1946-  Volume(issue)/page/year: 30,863,1975
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2450 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - antipsychotic
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   THERAP Therapie.  (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris,
   France)  V.1-    1946-  Volume(issue)/page/year: 30,863,1975
 
                            *** END OF RECORD ***